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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

dp-BREATH: Heat maps and probabilistic classification assisting the analysis of abnormal lung regions

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Cazzolato, Mirela T. [1] ; Scabora, Lucas C. [1] ; Nesso-Jr, Marcos R. ; Milano-Oliveira, Luis F. [2] ; Costa, Alceu F. [3] ; Kaster, Daniel S. [2] ; Koenigkam-Santos, Marcel [4] ; de Azevedo-Marques, Paulo Mazzoncini [4] ; Traina-Jr, Caetano ; Traina, Agma J. M. [5]
Total Authors: 10
[1] Univ Sao Paulo, Inst Math & Comp Sci, BR-13566590 Sao Carlos, SP - Brazil
[2] Univ Londrina, Dept Comp Sci, BR-86057970 Londrina, PR - Brazil
[3] Nesso-Jr, Jr., Marcos R., Univ Sao Paulo, Inst Math & Comp Sci, BR-13566590 Sao Carlos, SP - Brazil
[4] Univ Sao Paulo, Ribeirao Preto Med Sch, BR-14049900 Ribeirao Preto, SP - Brazil
[5] Traina-Jr, Jr., Caetano, Nesso-Jr, Jr., Marcos R., Univ Sao Paulo, Inst Math & Comp Sci, BR-13566590 Sao Carlos, SP - Brazil
Total Affiliations: 5
Document type: Journal article
Web of Science Citations: 2

Background and Objective: Identifying abnormalities in chest CT scans is an important and challenging task, demanding time and effort from specialists. Different parts of a single lung image may present both normal and abnormal characteristics. Thus, detecting a single lung as healthy (normal) or not is inaccurate. Methods: In this work we propose dp-BREATH, a method capable of detecting abnormalities in pulmonary tissue regions and directing the specialist's attention to the lung region containing them. It starts by highlighting regions that may indicate pulmonary abnormalities based on the healthy pulmonary tissue behavior using a superpixel-based approach and a heat map visualization. This is achieved by modeling regions of healthy tissue using a statistical model. All regions considered abnormal are modeled and classified according to their probability of containing each of the studied abnormalities. Further, dp-BREATH provides a better recognition of radiological patterns, with the likelihood of a selected lung region to contain abnormalities. Results: We validate the statistical model of healthy and abnormal detection using a representative dataset of chest CT scans. The model has shown almost no overlap between healthy and abnormal regions, and the detection of abnormalities presented precision higher than 86%, for all recall values. Additionally, the fitted models describing pulmonary radiological patterns present precision of up to 87%, with a high separation for three of five radiological patterns. Conclusions: dp-BREATH's heat map representation and its list of radiological patterns probabilities provided are intuitive methods to assist physicians during diagnosis. (c) 2019 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 16/17078-0 - Mining, indexing and visualizing Big Data in clinical decision support systems (MIVisBD)
Grantee:Agma Juci Machado Traina
Support type: Research Projects - Thematic Grants
FAPESP's process: 16/17330-1 - Storage and Navigation Operations on Graphs in Relational DBMS
Grantee:Lucas de Carvalho Scabora
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 18/24414-2 - A framework for integration of feature extraction techniques and complex databases for MIVisBD
Grantee:Mirela Teixeira Cazzolato
Support type: Scholarships in Brazil - Technical Training Program - Technical Training