Antibacterial surface based on new epoxy-amine networks from ionic liquid monomers

Author(s)

Livi, Sebastien ^{[1, 2, 3]} ; Lins, Luanda C. ^[4] ; Capeletti, Larissa B. ^{[1, 2]} ; Chardin, Charline ^[5] ; Halawani, Nour ^[3] ; Baudoux, Jerome ^[5] ; Cardoso, Mateus B. ^{[1, 2, 4]}

Affiliation

^[1] CNPEM, Lab Nacl Nanotecnol LNNano, Caixa Postal 6192, BR-13083970 Campinas, SP - Brazil

^[2] CNPEM, LNLS, Caixa Postal 6192, BR-13083970 Campinas, SP - Brazil

^[3] Univ Lyon, CNRS, UMR 5223, Ingn Mat Polymeres, INSA Lyon, F-69621 Villeurbanne - France

^[4] Univ Estadual Campinas, UNICAMP, Inst Quim, Caixa Postal 6154, BR-13083970 Campinas, SP - Brazil

^[5] Univ Normandie, CNRS, ENSICAEN, Lab Chim Mol & Thioorgan, 6 Blvd Marechal Juin, F-14050 Caen - France

• Document type: Journal article
• Source: EUROPEAN POLYMER JOURNAL; v. 116, p. 56-64, JUL 2019.
• Web of Science Citations: 1

Abstract

The design of new highly effective polymer materials as active surfaces or coatings against microorganisms such as Escherichia coli (E. coli) is a major challenge for public health. In the present work, novel imidazolium ionic liquid monomers (ILMs) having a similar structure of conventional Bisphenol A diglycidyl ether epoxy prepolymer (DGEBA) have been designed without requiring to the use of toxic and carcinogenic compounds i.e. Bisphenol A and epichlorohydrin. Then, a facile and efficient polyaddition reaction-based polymerization via a one step process was used in order to prepare unprecedented antibacterial epoxy-amine networks. The ultimate role of the monomers architecture on the epoxy conversion as well as on the reactivity of the epoxy-functionalized imidazolium ionic liquid monomers with an aliphatic amine (D-230) was investigated while the average molecular weight between crosslinks (Mc) and the relaxation temperature of the resulting networks were determined. Thus, new epoxy thermosets with an excellent thermal stability, high hydrophobic behavior and good storage modulus at room temperature were produced. Finally, antimicrobial tests against E. coli were performed for the first time on these new cross-linked epoxy networks leading to a very strong inhibition of E. coli biofilm formation (- 95%). (AU)

• FAPESP's process: 17/11060-5 - Development of injectable supramolecular hydrogels based in RGD peptide-modified
• Grantee: Luanda Chaves Vieira Lins
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 17/26471-0 - Design of new (multi)-dedicated silica nanoparticles based on ionic liquids for biomedical applications
• Grantee: Mateus Borba Cardoso
• Support Opportunities: Research Grants - Visiting Researcher Grant - International
• FAPESP's process: 15/25406-5 - Organizing matter: colloids formed by association of surfactants, polymers and nanoparticles
• Grantee: Watson Loh
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 17/01167-7 - Silica nanoparticles functionalized with carbohydrate oligomers and their interaction with the bacterial membrane
• Grantee: Larissa Brentano Capeletti
• Support Opportunities: Scholarships in Brazil - Post-Doctoral