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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Incorporation of Baccharis dracunculifolia DC (Asteraceae) leaf extract into phosphatidylcholine-cholesterol liposomes improves its anti-inflammatory effect in vivo

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Author(s):
Garcia de Figueiredo-Rinhel, Andrea Silva [1] ; de Andrade, Micassio Fernandes [1, 2] ; Landi-Librandi, Ana Paula [1] ; Caleiro Seixas Azzolini, Ana Elisa [1] ; Kabeya, Luciana Mariko [1] ; Bastos, Jairo Kenupp [3] ; Lucisano-Valim, Yara Maria [1]
Total Authors: 7
Affiliation:
[1] Univ Sao Paulo, Dept Fis & Quim, Fac Ciencias Farmaceut Ribeirao Preto, Ribeirao Preto - Brazil
[2] Univ Sao Paulo, Dept Bioquim & Imunol, Fac Med Ribeirao Preto, Ribeirao Preto - Brazil
[3] Univ Sao Paulo, Dept Ciencias Farmaceut, Fac Ciencias Farmaceut Ribeirao Preto, Ribeirao Preto - Brazil
Total Affiliations: 3
Document type: Journal article
Source: NATURAL PRODUCT RESEARCH; v. 33, n. 17, p. 2521-2525, SEP 2 2019.
Web of Science Citations: 2
Abstract

The aerial parts of Baccharis dracunculifolia (BdE) is used in the Brazilian folk medicine to treat inflammatory conditions. Here we examined the ability of free and liposomal BdE to modulate reactive oxygen species generation in human neutrophils in vitro and zymosan-induced acute joint inflammation in Wistar rats. We prepared biocompatible liposomes of soya phosphatidylcholine and cholesterol with low diameter, homogeneous size distribution, and neutral surface charge. Free BdE decreased joint swelling, total leucocyte and neutrophil infiltration, and the synovial levels of tumour necrosis factor-alpha and interleukins 6 and 1 beta. Incorporation of BdE into liposomes preserved its capacity to inhibit the neutrophil superoxide anion and total reactive oxygen species generation, and improved its anti-inflammatory effect in vivo by decreasing the effective BdE dose by nearly sixfold. The same liposome type lowered the effective dose of caffeic acid by nearly sixteenfold. Therefore, incorporation of BdE into phosphatidylcholine-cholesterol liposomes improves its anti-inflammatory effect. {[}GRAPHICS] . (AU)

FAPESP's process: 12/23541-4 - In vitro evaluation of antioxidant and anti-inflammatory derivatives 3-phenylcoumarins in human neutrophils stimulated and in animal models of arthritis.
Grantee:Micássio Fernandes de Andrade
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 10/19504-0 - Study of the antioxidant activity mechanism of Baccharis dracunculifolia(Asteraceae) in neutrophils and evaluation of this effect on rheumatoid arthritis model
Grantee:Andréa Silva Garcia de Figueiredo Rinhel
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 13/20810-7 - Systematic study of the molecular mechanisms involved in the inhibition of the oxidative metabolism of the stimulated neutrophils by the Baccharis dracunculifolia, 3-phenylcoumarin derivatives and 3,5,7-triidroxiflavonaimplications on the RA therapeutics
Grantee:Yara Maria Lucisano Valim
Support Opportunities: Regular Research Grants
FAPESP's process: 13/00927-7 - Molecular dynamics simulations for the identification of bioactive molecules: inhibitors of the interaction between the dengue virus envelope glycoprotein and cellular C-type lectins
Grantee:Leandro Oliveira Bortot
Support Opportunities: Scholarships in Brazil - Doctorate (Direct)