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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Pulsatile Discharge from Polymeric Scaffolds: A Novel Method for Modulated Drug Release

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Author(s):
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Campana, Patricia T. [1] ; Marletta, Alexandre [2] ; Piovesan, Erick [2] ; Francisco, Kelliton J. M. [1] ; Neto, Francisco V. R. [2] ; Petrini Jr, Leandro ; Silva, Thiago R. [3] ; Machado, Danilo [2] ; Basoli, Francesco [4] ; Oliveira Jr, Osvaldo N. ; Licoccia, Silvia [5] ; Traversa, Enrico [6]
Total Authors: 12
Affiliation:
[1] Univ Sao Paulo, Sch Arts Sci & Humanities, Arlindo Bettio Av 1000, BR-03828000 Sao Paulo - Brazil
[2] Fed Univ Uberlandia UFU, Inst Phys, Joao Naves de Avila Av 2121, BR-38408100 Uberlandia, MG - Brazil
[3] Petrini Jr, Jr., Leandro, Univ Sao Paulo, Sch Arts Sci & Humanities, Arlindo Bettio Av 1000, BR-03828000 Sao Paulo - Brazil
[4] Univ Rome Campus Biomed Roma, Dept Engn, Alvaro del Portillo St 21, I-00128 Rome - Italy
[5] Univ Roma Tor Vergata, Dept Chem Sci & Technol, Via Ric Sci St, I-00133 Rome - Italy
[6] Univ Elect Sci & Technol China, Sch Mat & Energy, 2006 Xiyuan Rd, Chengdu 611731, Sichuan - Peoples R China
Total Affiliations: 6
Document type: Journal article
Source: BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN; v. 92, n. 7, p. 1237-1244, JUL 2019.
Web of Science Citations: 0
Abstract

Controlled drug release holds promise to revolutionize medicine, particularly if short-term and long-term release can be combined in a single system. We present here a new pulsatile release system, in which the pulses were achieved using 3D scaffolds of poly(L-lactic acid), PLLA. From a morphological characterization of the scaffold's surfaces, before and after releasing experiments at distinct pHs, we infer that release is governed by electrostatic interactions and the fractal geometry of the scaffolds. Furthermore, the scaffold can present short-term (within hours) or long-term (several days long) releasing profiles by varying the pH, which opens the way for unprecedented drug release control. (AU)

FAPESP's process: 10/06728-8 - Introduction of growing factors into polymeric scaffolds for biomimetic tissues improvement.
Grantee:Patricia Targon Campana
Support Opportunities: Regular Research Grants
FAPESP's process: 12/13596-6 - Fluorescence spectroscopy for biological systems studies and their applications at biomaterials development.
Grantee:Patricia Targon Campana
Support Opportunities: Regular Research Grants
FAPESP's process: 13/14262-7 - Nanostructured films from biologically-relevant materials
Grantee:Osvaldo Novais de Oliveira Junior
Support Opportunities: Research Projects - Thematic Grants