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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Schistosoma mansoni venom allergen-like proteins: phylogenetic relationships, stage-specific transcription and tissue localization as predictors of immunological cross-reactivity

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Farias, Leonardo P. [1, 2] ; Chalmers, Lain W. [3] ; Perally, Samirah [3] ; Rofatto, Henrique K. [1] ; Jackson, Colin J. [3] ; Brown, Martha [3] ; Khouri, I, Mariana ; Barbosa, Mayra M. F. [1, 4] ; Hensbergen, Paul J. [5] ; Hokke, Cornelis H. [6] ; Leite, Luciana C. C. [1] ; Hoffmann, Karl F. [3]
Total Authors: 12
[1] Inst Butantan, Ctr Biotecnol, Av Vital Brasil 1500, BR-05503900 Sao Paulo, SP - Brazil
[2] I, Fundacao Oswaldo Cruz FIOCRUZ, Inst Goncalo Moniz, Rua Waldemar Falcao, Salvador, BA - Brazil
[3] Aberystwyth Univ, Inst Biol Environm & Rural Sci, Aberystwyth SY23 3FG, Dyfed - Wales
[4] Univ Sao Paulo, Programa Posgrad Interunidades Biotecnol, Sao Paulo, SP - Brazil
[5] Leiden Univ, Ctr Prote & Metabol, Med Ctr, POB 9600, NL-2300 RC Leiden - Netherlands
[6] Leiden Univ, Dept Parasitol, Med Ctr, POB 9600, NL-2300 RC Leiden - Netherlands
Total Affiliations: 6
Document type: Journal article
Source: International Journal for Parasitology; v. 49, n. 8, p. 593-599, JUL 2019.
Web of Science Citations: 0

Schistosoma mansoni venom allergen-like proteins (SmVALs) are part of a diverse protein superfamily partitioned into two groups (group 1 and group 2). Phylogenetic analyses of group 1 SmVALs revealed that members could be segregated into subclades (A-D); these subclades share similar gene expression patterns across the parasite lifecycle and immunological cross-reactivity. Furthermore, whole-mount in situ hybridization demonstrated that the phylogenetically, transcriptionally and immunologically-related SmVAL4, 10, 18 and 19 (subclade C) were all localized to the pre-acetabular glands of immature cercariae. Our results suggest that SmVAL group 1 phylogenetic relationships, stage-specific transcriptional profiles and tissue localization are predictive of immunological cross-reactivity. (C) 2019 The Authors. Published by Elsevier Ltd on behalf of Australian Society for parasitology. (AU)

FAPESP's process: 12/23124-4 - Investigating the effector mechanisms of the Schistosoma mansoni attenuated vaccine by Systems Vaccinology
Grantee:Luciana Cezar de Cerqueira Leite
Support type: Regular Research Grants
FAPESP's process: 08/57946-5 - Investigating the immunomodulatory properties of venom allergen like proteins from Schistosoma mansoni
Grantee:Leonardo Paiva Farias
Support type: Scholarships abroad - Research
FAPESP's process: 07/07685-8 - Biochemical and molecular characterization of the Nucleotide Pyrophosphtases/Phosphodiesterases (NPPs) from Schistosoma mansoni and its potencial vaccine investigation
Grantee:Henrique Krambeck Rofatto
Support type: Scholarships in Brazil - Doctorate (Direct)