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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Determination of Ethofumesate-2-hydroxy Stereolability by Dynamic HPLC

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Author(s):
Perovani, Icaro Salgado [1] ; Moraes de Oliveira, Anderson Rodrigo [1]
Total Authors: 2
Affiliation:
[1] Univ Sao Paulo, Fac Filosofia Ciencias & Letras Ribeirao Preto, Dept Quim, Ribeirao Preto, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: SEPARATION SCIENCE PLUS; v. 1, n. 12, p. 771-775, DEC 2018.
Web of Science Citations: 0
Abstract

Evaluating stereolability of target chiral chemical is pivotal when developing enantioselective studies. Ethofumesate-2-hydroxy is one of the main metabolites of ethofumesate, a chiral herbicide currently marketed as racemate. In order to perform enantioselective pharmacokinetic and metabolism studies, the stereolability of susceptible molecules should be evaluated. Based on that, dynamic high-performance liquid chromatography experiments were performed to evaluate ethofumesate-2-hydroxy enantiomerization process on-column. The thermodynamic results helped understand that ethofumesate-2-hydroxy enantiomerization is a bimolecular process assisted by acid and base catalysis. The enantiomerization barrier determined suggested that ethofumesate-2-hydroxy single enantiomers may undergo extensive racemization at ambient temperature turning ethofumesate-2-hydroxy enantioselective studies into an unfeasible task. (AU)

FAPESP's process: 14/50945-4 - INCT 2014: National Institute for Alternative Technologies of Detection, Toxicological Evaluation and Removal of Micropollutants and Radioactivies
Grantee:Maria Valnice Boldrin
Support type: Research Projects - Thematic Grants
FAPESP's process: 18/07534-4 - Development of chromatographic / electrophoretic methods to be further applied in in vitro enzymatic inhibition studies and prediction of drug interactions of chiral pesticides - phase 2
Grantee:Anderson Rodrigo Moraes de Oliveira
Support type: Regular Research Grants