| Full text | |
| Author(s): |
Total Authors: 2
|
| Affiliation: | [1] Univ Sao Paulo, Fac Filosofia Ciencias & Letras Ribeirao Preto, Dept Quim, Ribeirao Preto, SP - Brazil
Total Affiliations: 1
|
| Document type: | Journal article |
| Source: | SEPARATION SCIENCE PLUS; v. 1, n. 12, p. 771-775, DEC 2018. |
| Web of Science Citations: | 0 |
| Abstract | |
Evaluating stereolability of target chiral chemical is pivotal when developing enantioselective studies. Ethofumesate-2-hydroxy is one of the main metabolites of ethofumesate, a chiral herbicide currently marketed as racemate. In order to perform enantioselective pharmacokinetic and metabolism studies, the stereolability of susceptible molecules should be evaluated. Based on that, dynamic high-performance liquid chromatography experiments were performed to evaluate ethofumesate-2-hydroxy enantiomerization process on-column. The thermodynamic results helped understand that ethofumesate-2-hydroxy enantiomerization is a bimolecular process assisted by acid and base catalysis. The enantiomerization barrier determined suggested that ethofumesate-2-hydroxy single enantiomers may undergo extensive racemization at ambient temperature turning ethofumesate-2-hydroxy enantioselective studies into an unfeasible task. (AU) | |
| FAPESP's process: | 14/50945-4 - INCT 2014: National Institute for Alternative Technologies of Detection, Toxicological Evaluation and Removal of Micropollutants and Radioactivies |
| Grantee: | Maria Valnice Boldrin |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 18/07534-4 - Development of chromatographic / electrophoretic methods to be further applied in in vitro enzymatic inhibition studies and prediction of drug interactions of chiral pesticides - Phase 2 |
| Grantee: | Anderson Rodrigo Moraes de Oliveira |
| Support Opportunities: | Regular Research Grants |