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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Masseter corticomotor excitability is decreased after intramuscular administration of nerve growth factor

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Author(s):
Costa, Yuri M. [1] ; Exposto, Fernando G. [2, 3] ; Kothari, Mohit [2, 4, 5] ; Castrillon, Eduardo E. [2, 3] ; Conti, Paulo Cesar R. [6] ; Bonjardim, Leonardo R. [7] ; Svensson, Peter [8, 2, 3]
Total Authors: 7
Affiliation:
[1] Univ Estadual Campinas, Piracicaba Dent Sch, Dept Physiol Sci, Av Limeira 901, BR-13414903 Piracicaba - Brazil
[2] SCON, Aarhus - Denmark
[3] Aarhus Univ, Dept Dent & Oral Hlth, Sect Orofacial Pain & Jaw Funct, Aarhus - Denmark
[4] Aarhus Univ, Dept Clin Med, Aarhus - Denmark
[5] Hammel Neurorehabil & Univ Res Clin, Reg Hosp, Hammel - Denmark
[6] Univ Sao Paulo, Bauru Sch Dent, Dept Prosthodont, Bauru - Brazil
[7] Univ Sao Paulo, Bauru Sch Dent, Dept Biol Sci, Sect Head & Face Physiol, Bauru - Brazil
[8] Karolinska Inst, Dept Dent Med, Huddinge - Sweden
Total Affiliations: 8
Document type: Journal article
Source: EUROPEAN JOURNAL OF PAIN; v. 23, n. 9 JULY 2019.
Web of Science Citations: 0
Abstract

Background Quantification of motor-evoked potentials (MEPs) can contribute to better elucidate the central modulation of motor pathways in response to nociceptive inputs. The primary aim of this study was to assess the modulatory effects of nerve growth factor (NGF) injection on masseter corticomotor excitability. Methods The healthy participants of this randomized, double blind placebo-controlled experiment were assigned to have injected into the right masseter muscle either NGF (n = 25) or isotonic saline (IS, n = 17). The following variables were assessed at baseline and 48 hr after the injection: right masseter MEP amplitude and corticomotor mapping and clinical assessment of jaw pain intensity and function. Repeated Measures ANOVA was applied to the data. Results NGF caused jaw pain and increased jaw functional disability after the injection (p < 0.050). Also, the participants in the NGF group decreased the MEP amplitude (p < 0.001) but the IS group did not present any significant modulation after the injection (p > 0.050). Likewise, the participants in the NGF group reduced corticomotor map area and volume (p < 0.001), but the IS group did not show any significant corticomotor mapping changes after the injection (p > 0.050). Finally, there was a significant correlation between the magnitude of decreased corticomotor excitability and jaw pain intensity on chewing 48 hr after the NGF injection (r = -0.51, p = 0.009). Conclusion NGF-induced masseter muscle soreness can significantly reduce jaw muscle corticomotor excitability, which in turn is associated with lower jaw pain intensity and substantiates the occurrence of central changes that most likely aim to protect the musculoskeletal orofacial structures. Significance Intramuscular administration of nerve growth factor into masseter muscle causes inhibitory corticomotor plasticity, which likely occurs to prevent further damage and seems associated with lower pain intensity on function. (AU)

FAPESP's process: 15/09913-4 - The effect of cutaneous afferents in the mechanical somatosensory profile of masticatory myofascial pain.
Grantee:Yuri Martins Costa
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 18/00614-2 - Effects of experimental pain and local anesthesia on motor cortex excitability and its relationship with muscle sensitivity
Grantee:Yuri Martins Costa
Support Opportunities: Scholarships abroad - Research Internship - Post-doctor