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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Neuroprotective Effects of Kinin B2 Receptor in Organotypic Hippocampal Cultures of Middle-Aged Mice

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Author(s):
Toricelli, Mariana [1, 2] ; Evangelista, Sebastiana Ribeiro [1, 2] ; Oliveira, Larissa Rolim [2] ; Viel, Tania Araujo [3, 1] ; Buck, Hudson Sousa [1, 2]
Total Authors: 5
Affiliation:
[1] Res Grp Neuropharmacol Aging ReGNA, Sao Paulo - Brazil
[2] Santa Casa Sao Paulo Sch Med Sci, Dept Physiol Sci, Sao Paulo - Brazil
[3] Univ Sao Paulo, Sch Arts Sci & Humanities, Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: FRONTIERS IN AGING NEUROSCIENCE; v. 11, JUL 12 2019.
Web of Science Citations: 0
Abstract

Aging is a multifactorial phenomenon that results in several changes at cellular and molecular levels and is considered the main risk factor for some neurodegenerative diseases. Several evidence show the participation of the kallikrein-kinin system (KKS) in neurodegeneration and this system has been associated with inflammation and immunogenic responses in the central and peripheral systems by the activation of the B1 and B2 receptors. Previous work by our group showed that bradykinin (BK) and the B2 receptor played a possible role in neuroprotection. Therefore, the objective of this study was to evaluate the participation of B2 receptors in cell viability, neuroinflammatory response and neuroplasticity in organotypic hippocampal cultures (OHCs) of 6- and 12-month-old mice. It was observed that activation of the B2 receptor by bradykinin decreased the inflammatory response and increased plasticity in 12-month-old slices. Conversely, there was an increase in the inflammatory response and a decrease in neural plasticity in the 6-month-old slices. In both ages, an increase in cell viability was observed. This data suggests that the function of the kinin B2 receptor in the hippocampus is modulated by age, providing neuroprotective action in old age. (AU)

FAPESP's process: 13/13656-1 - Study of the neuroprotective role of kinin B2 receptor in the Alzheimer's Disease
Grantee:Hudson de Sousa Buck
Support type: Regular Research Grants
FAPESP's process: 17/21655-6 - Study of the cell survival modulation by B2 receptor for bradykinin and its impact on neuroinflamation in organotypic hippocampal culture of transgenic mice for Alzheimer's disease.
Grantee:Mariana Toricelli Pinto
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 16/07115-6 - Translational study of strategies and biomarkers to promote healthspan
Grantee:Tânia Araújo Viel
Support type: Regular Research Grants