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Translational study of strategies and biomarkers to promote healthspan

Abstract

The aging process is attracting the world's attention, once the aged phase can bring many debilitating chronic diseases. In recent years, our research team has shown the benefits of the environmental enrichment and the administration of lithium ions in microdoses for the memory improvement in both human beings and mice, which can lead to healthspan. Besides, we also verified the role of the cholinergic system for the neuroplasticity. Our hypothesis is that the nutritional enrichment with lithium and the use of the enriched environment are efficient strategies for the prevention and treatment of cognitive disabilities that take place along the elderly. These strategies can promote neuroplasticity, reduce stress and alter the chronic inflammatory pattern in rodents and humans. The aim of this work is to evaluate the changes in biomarkers for neuroplasticity, stress and inflammation in human beings and animals submitted or not to strategies that can lead to a healthful aging. In animals, the effects of lithium will be observed in senescence-accelerated mice (SAMP-8). In human beings, the observation will be done in volunteers diagnosed with Alzheimer's disease and treated or not with lithium in microdoses. The analysis of biomarkers for neuroplasticity and the study of the cholinergic system will be done using brain samples of the LOU rat, a model of healthful aging, comparing to brain samples of very old people, from a human brain bank, diagnosed or not with Alzheimer's disease. In this way, we intend to make a translational analysis of the molecular mechanisms related to longevity and verify the influence of the different treatments, as well as the role of the cholinergic system in this process. (AU)

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VEICULO: TITULO (DATA)

Scientific publications (7)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
TORICELLI, MARIANA; EVANGELISTA, SEBASTIANA RIBEIRO; BUCK, HUDSON SOUSA; VIEL, TANIA ARAUJO. Microdose Lithium Treatment Reduced Inflammatory Factors and Neurodegeneration in Organotypic Hippocampal Culture of Old SAMP-8 Mice. Cellular and Molecular Neurobiology, v. 41, n. 7, p. 1509-1520, OCT 2021. Web of Science Citations: 2.
TORICELLI, MARIANA; PEREIRA, ARTHUR ANTONIO RUIZ; SOUZA ABRAO, GUILHERME; MALERBA, HELENA NASCIMENTO; MAIA, JULIA; BUCK, HUDSON SOUSA; VIEL, TANIA ARAUJO. Mechanisms of neuroplasticity and brain degeneration: strategies for protection during the aging process. NEURAL REGENERATION RESEARCH, v. 16, n. 1, p. 58-67, JAN 2021. Web of Science Citations: 0.
NUNES, MARIELZA ANDRADE; TORICELLI, MARIANA; SCHOWE, NATALIA MENDES; MALERBA, HELENA NASCIMENTO; DONG-CRESTE, KARIS ESTER; AZEVEDO TUMA FARAH, DANIELA MOURA; DE ANGELIS, KATIA; IRIGOYEN, MARIA CLAUDIA; GOBEIL, FERNAND; VIEL, TANIA ARAUJO; BUCK, HUDSON SOUSA. Kinin B2 Receptor Activation Prevents the Evolution of Alzheimer's Disease Pathological Characteristics in a Transgenic Mouse Model. PHARMACEUTICALS, v. 13, n. 10 OCT 2020. Web of Science Citations: 0.
TORICELLI, MARIANA; EVANGELISTA, SEBASTIANA RIBEIRO; BUCK, HUDSON SOUSA; VIEL, TANIA ARAUJO. Microdose Lithium Treatment Reduced Inflammatory Factors and Neurodegeneration in Organotypic Hippocampal Culture of Old SAMP-8 Mice. Cellular and Molecular Neurobiology, JUL 2020. Web of Science Citations: 0.
TORICELLI, MARIANA; EVANGELISTA, SEBASTIANA RIBEIRO; OLIVEIRA, LARISSA ROLIM; VIEL, TANIA ARAUJO; BUCK, HUDSON SOUSA. Neuroprotective Effects of Kinin B2 Receptor in Organotypic Hippocampal Cultures of Middle-Aged Mice. FRONTIERS IN AGING NEUROSCIENCE, v. 11, JUL 12 2019. Web of Science Citations: 0.
TELLES-LONGUI, MILENA; MOURELLE, DANILO; SCHOWE, NATALIA MENDES; CIPOLLI, GABRIELA CABETT; MALERBA, HELENA NASCIMENTO; BUCK, HUDSON SOUSA; VIEL, TANIA ARAUJO. alpha 7 nicotinic ACh receptors are necessary for memory recovery and neuroprotection promoted by attention training in amyloid-beta-infused mice. British Journal of Pharmacology, v. 176, n. 17 JULY 2019. Web of Science Citations: 0.
BALTHAZAR, JANAINA; SCHOWE, NATALIA MENDES; CIPOLLI, GABRIELA CABETT; BUCK, HUDSON SOUSA; VIEL, TANIA ARAUJO. Enriched Environment Significantly Reduced Senile Plaques in a Transgenic Mice Model of Alzheimer's Disease, Improving Memory. FRONTIERS IN AGING NEUROSCIENCE, v. 10, SEP 26 2018. Web of Science Citations: 1.

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