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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Maternal nutrient intake and fetal gastroschisis: A case-control study

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Author(s):
Centofanti, Sandra F. [1] ; Francisco, Rossana P. V. [1] ; Phillippi, Sonia T. [2] ; Galletta, Marco A. K. [1] ; Sousa, Ana M. S. [1] ; Rodrigues, Agatha S. [3, 1] ; Curi, Rui [4] ; Brizot, Maria L. [1]
Total Authors: 8
Affiliation:
[1] Univ Sao Paulo, Fac Med FMUSP, Dept Obstet & Gynecol, Sao Paulo - Brazil
[2] Univ Sao Paulo, Fac Publ Hlth, Dept Nutr, Sao Paulo - Brazil
[3] Univ Sao Paulo, Inst Math & Stat, Dept Stat, Sao Paulo - Brazil
[4] Univ Cruzeiro Sul, Post Grad Program Hlth Sci, Sao Paulo - Brazil
Total Affiliations: 4
Document type: Journal article
Source: AMERICAN JOURNAL OF MEDICAL GENETICS PART A; v. 179, n. 8, p. 1535-1542, AUG 2019.
Web of Science Citations: 0
Abstract

Fetal gastroschisis is a paraumbilical abdominal wall defect with herniation of the abdominal organs. This multifactorial malformation occurs in young pregnant women, and the underlying cause of the disease remains unknown; however, nutritional factors may play a role in its development. This case-control study explored the association of maternal nutrient intake with the occurrence of gastroschisis. The gastroschisis group (GG) comprised 57 pregnant women with fetuses with gastroschisis, and the control group (CG) comprised 114 pregnant women with normal fetuses matched for maternal age, gestational age, and preconception body mass index classification. Nutritional assessments related to the preconception period were obtained using the food consumption frequency questionnaire, and nutrient intakes were calculated using nutrition programs. The median daily calorie intake was higher (2,382.43 vs. 2,198.81; p = .041) in the GG than in the CG. The median intake of methionine (763.89 vs. 906.34; p = .036) and threonine (1,248.34 vs. 1,437.01; p = .018) was lower in the GG than in the CG. Pregnant women with fetuses with gastroschisis have a diet characterized by higher calorie intake and lower levels of essential amino acids (methionine and threonine) during the preconception period than pregnant women with normal fetuses. (AU)

FAPESP's process: 15/09859-0 - Fetal gastroschisis: maternal nutritional evaluation and serum fatty acids profile
Grantee:Maria de Lourdes Brizot
Support Opportunities: Regular Research Grants