ACE GENE PLAYS A KEY ROLE IN REDUCING BLOOD PRESSURE IN THE HYPERINTENSIVE ELDERLY AFTER RESISTANCE TRAINING

Author(s)

Montrezol, Fabio T. ^[1] ; Marinho, Rodolfo ^[2] ; da Mota, Gloria de F. A. ^[3] ; D'Almeida, Vania ^[4] ; de Oliveira, Edilamar M. ^[3] ; Gomes, Ricardo J. ^[1] ; Medeiros, Alessandra ^[1]

Affiliation

^[1] Univ Fed Sao Paulo, Dept Biosci, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Canc Metab Res Grp, Inst Biomed Sci, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Lab Biochem & Mol Biol Exercise, Sao Paulo - Brazil

^[4] Univ Fed Sao Paulo, Dept Psychobiol, Sao Paulo - Brazil

• Document type: Journal article
• Source: JOURNAL OF STRENGTH AND CONDITIONING RESEARCH; v. 33, n. 4, p. 1119-1129, APR 2019.
• Web of Science Citations: 0

Abstract

Hypertension is a difficult disease to control and exercise training plays a key role in hypertension control. Some individuals are not responsive to exercise training; so, we highlight the polymorphism of I allele of angiotensin-converting enzyme (ACE) as a factor responsible for this lack of responsiveness. The aim of this study was to evaluate the influence of ACE insertion/deletion genotypes on effects of resistance training on blood pressure (BP) and chronic inflammation. Eighty-six hypertensive volunteers, aged between 60 and 80, were evaluated. They performed 16 weeks of resistance training at 50% of 1 maximal repetition. The greatest benefits were seen on homozygous of the Insertion allele, whom presented reduction of systolic blood pressure (SBP: 129.31 +/- 13.34 vs. 122.56 +/- 9.68 mm Hg, p < 0.001) and diastolic blood pressure (DBP: 79.18 +/- 8.05 vs. 70.12 +/- 7.71 mm Hg, p < 0.01) during daytime period, and in 24-hour period (SBP: 127.12 +/- 13.65 vs. 121.06 +/- 9.68 mm Hg, p < 0.001 and DBP: 71.87 +/- 8.39 vs. 68.75 +/- 8.72 mm Hg, p < 0.05) and also increased circulating adiponectin levels (4.04 +/- 1.79 vs. 6.00 +/- 2.81 ng.ml(-1), p < 0.01). Other genotypes showed no changes in BP and biochemical parameters. Our results suggest a cardio protective factor of I allele because only those homozygous showed reductions in BP and increases in adiponectin. (AU)

• FAPESP's process: 11/23830-3 - Effect of resistance training on blood pressure of elderly hypertensive patients: influence of angiotensin-converting enzyme polymorphism
• Grantee: Ricardo Jose Gomes
• Support Opportunities: Regular Research Grants