Updating the role of matrix metalloproteinases in mineralized tissue and related diseases

Author(s)

Cintia Kazuko Tokuhara ^[1] ; Mariana Rodrigues Santesso ^[2] ; Gabriela Silva Neubern de Oliveira ^[3] ; Talita Mendes da Silva Ventura ^[4] ; Julio Toshimi Doyama ^[5] ; Willian Fernando Zambuzzi ^[6] ; Rodrigo Cardoso de Oliveira ^[7]

Affiliation

^[1] Universidade de São Paulo. Faculdade de Odontologia de Bauru. Departamento de Ciências Biológicas - Brasil

^[2] Universidade de São Paulo. Faculdade de Odontologia de Bauru. Departamento de Ciências Biológicas - Brasil

^[3] Universidade de São Paulo. Faculdade de Odontologia de Bauru. Departamento de Ciências Biológicas - Brasil

^[4] Universidade de São Paulo. Faculdade de Odontologia de Bauru. Departamento de Ciências Biológicas - Brasil

^[5] Universidade Estadual Paulista Júlio de Mesquita Filho - Brasil

^[6] Universidade Estadual Paulista Júlio de Mesquita Filho - Brasil

^[7] Universidade de São Paulo. Faculdade de Odontologia de Bauru. Departamento de Ciências Biológicas - Brasil

• Document type: Journal article
• Source: Journal of Applied Oral Science; v. 27, 2019-09-09.

Abstract

Abstract Bone development and healing processes involve a complex cascade of biological events requiring well-orchestrated synergism with bone cells, growth factors, and other trophic signaling molecules and cellular structures. Beyond health processes, MMPs play several key roles in the installation of heart and blood vessel related diseases and cancer, ranging from accelerating metastatic cells to ectopic vascular mineralization by smooth muscle cells in complementary manner. The tissue inhibitors of MMPs (TIMPs) have an important role in controlling proteolysis. Paired with the post-transcriptional efficiency of specific miRNAs, they modulate MMP performance. If druggable, these molecules are suggested to be a platform for development of “smart” medications and further clinical trials. Thus, considering the pleiotropic effect of MMPs on mammals, the purpose of this review is to update the role of those multifaceted proteases in mineralized tissues in health, such as bone, and pathophysiological disorders, such as ectopic vascular calcification and cancer. (AU)

• FAPESP's process: 14/22689-3 - Microvesicle/proteins-mediated paracrine signaling among bone and endothelial cells during bone development and regeneration
• Grantee: Willian Fernando Zambuzzi
• Support Opportunities: Research Grants - Young Investigators Grants
• FAPESP's process: 10/02025-2 - Matrix metalloproteinases expression in osteoblasts of two strains of mice under the effect of fluoride: a comparative approach in vitro
• Grantee: Rodrigo Cardoso de Oliveira
• Support Opportunities: Regular Research Grants