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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Antifibrotic effects of total or partial application of amniotic membrane in hepatic fibrosis

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Author(s):
KARINA M. MAMEDE [1] ; LUCIANA B. SANTANNA [2]
Total Authors: 2
Affiliation:
[1] Universidade do Vale do Paraíba. Instituto de Pesquisa e Desenvolvimento. Laboratório de Histologia e Terapia Regenerativa - Brasil
[2] Universidade do Vale do Paraíba. Instituto de Pesquisa e Desenvolvimento. Laboratório de Histologia e Terapia Regenerativa - Brasil
Total Affiliations: 2
Document type: Journal article
Source: Anais da Academia Brasileira de Ciências; v. 91, n. 3 2019-09-16.
Abstract

Abstract: Liver fibrosis is the final common pathway of chronic liver diseases, having cirrhosis as a possible progression, which has liver transplantation as the only effective treatment. Human amniotic membrane represents a potential strategy as a therapy for liver fibrosis, due to its anti-inflammatory, anti-fibrotic and immunomodulatory properties. The aim of this study was to evaluate amniotic membrane effects as a treatment for hepatic fibrosis induced in rats by bile duct ligation (BDL), verifying alterations between two different forms of amniotic membrane application, around all the lobes of the liver and around only one lobe of the liver. Two weeks after inducing fibrosis, an amniotic membrane fragment was applied to the surface of the liver, covering it either totally or partially. Four weeks later, the animals were euthanized and liver samples were collected. Histopathological and quantitative analyses demonstrated fibrosis severity decrease and an extremely significant reduction in the deposition of collagen in the groups treated with amniotic membrane, particularly when the amniotic membrane was applied in only one liver lobe. It is concluded that the amniotic membrane acted on the repair of liver fibrosis in both modes of application, with the application of the amniotic membrane around only one hepatic lobe being more effective in reducing the severity / extent of fibrosis. (AU)

FAPESP's process: 16/10827-8 - Mechanisms of action of fresh and cryopreserved amniotic membrane in the repair of liver fibrosis induced in rats.
Grantee:Luciana Barros Sant'Anna
Support Opportunities: Regular Research Grants