Association between the timing of maternal vaccination and newborns' anti-pertussis toxin antibody levels

Author(s):Show less -

Vaz-de-Lima, Lourdes R. A. ^[1] ; Sato, Helena Keico ^[2] ; Fernandes, Eder Gatti ^[2] ; Sayuri Sato, Ana Paula ^[3] ; Pawloski, Lucia C. ^[4] ; Tondella, Maria Lucia ^[4] ; de Brito, Cyro A. ^[1] ; Luna, Expedito J. A. ^[5] ; Carvalhanas, Telma Regina M. P. ^[6] ; de Castilho, Euclides A. ^[7] ; de Souza, Edna M. ^[8] ; Atobe, Jane H. ^[8] ; Oliveira, Carmem A. F. ^[8] ; Leite, Daniela ^[9] ; Silva, Marcela R. ^[10] ; Mariani-Neto, Corintio ^[11] ; Bersusa, Ana ^[11] ; Calabresi, Rita de Cassia S. ^[12] ; dos Santos, Rosemary A. ^[12] ; Tesser, Diva T. ^[12] ; Bacciotte Ramos, Maria Ligia ^[13] ; Working, Maternal Pertussis Vaccine

Affiliation:Show less -

^[1] Adolfo Lutz Inst, Ctr Imunol, Sao Paulo - Brazil

^[2] Coordenadoria Controle Doencas Secretaria Estado, Ctr Vigilancia Epidemiol Prof Alexandre Vranjac, Div Imunizacao, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Fac Saude Publ, Dept Epidemiol, Sao Paulo - Brazil

^[4] Ctr Dis Control & Prevent, Pertussis & Diphtheria Lab, Div Bacterial Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA - USA

^[5] Univ Sao Paulo, Inst Med Trop, Sao Paulo - Brazil

^[6] Coordenadoria Controle Doencas Secretaria Estado, Div Doencas Transmissao Resp, Ctr Vigilancia Epidemiol Prof Alexandre Vranjac, Sao Paulo, SP - Brazil

^[7] Univ Sao Paulo, Fac Med, Dept Med Prevent, Sao Paulo - Brazil

^[8] Adolfo Lutz Inst, Immunol Ctr, Sao Paulo - Brazil

^[9] Adolfo Lutz Inst, Natl Reference Ctr Pertussis, Bacteriol Ctr, Sao Paulo - Brazil

^[10] Secretaria Estado Saude SP, Resp Div, Ctr Vigilancia Epidemiol, Sao Paulo - Brazil

^[11] Hosp & Maternidade Leonor Mendes Barros, Sao Paulo - Brazil

^[12] Hosp Maternidade Interlagos, Sao Paulo - Brazil

^[13] Secretaria Municipal Saude SP, Coordenacao Vigilancia Saude, Ctr Controle Doencas, Sao Paulo - Brazil

• Document type: Journal article
• Source: Vaccine; v. 37, n. 36, p. 5474-5480, AUG 23 2019.
• Web of Science Citations: 1

Abstract

Background: Pertussis remains an important global public health concern, despite the presence of extensive immunization programs. Incidence and severity of pertussis are typically higher in neonates and young infants. As a strategy to protect these young infants, maternal vaccination with Tdap (tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis) has been recommended in Brazil. The objective of this study was to evaluate the effects of Tdap vaccination during pregnancy on the anti-pertussis toxin (PT) IgG response in mothers and their infants at birth. Material and methods: Maternal and cord blood samples were collected from vaccinated (n = 243) and unvaccinated (n = 75) pregnant women, at the time of delivery, from July 2015 to August 2016 in Sao Paulo, Brazil. Anti-PT IgG antibodies were quantified by Enzyme-Linked Immunosorbent Assay (ELISA) and geometric mean concentrations (GMC) were calculated. Relationship between timing of vaccination and antibody concentrations were evaluated. Results: Maternal and cord blood GMCs among the vaccinated group were 5.4 and 5.6 fold higher {[}66.5 International Units (IU)/mL and 89.8 IU/mL] compared to the unvaccinated group (12.4 IU/mL and 16.1 IU/mL), respectively (p < 0.001). Higher anti-PT IgG GMCs were observed when vaccination occurred >= 60 days before delivery compared to <60 days, suggesting that vaccination early in the third trimester may be more effective than later in pregnancy. Conclusion: Tdap maternal vaccination results in significantly higher anti-FT IgG in newborn infants and supports the current recommendation of the Brazilian Immunization Program. (C) 2019 Elsevier Ltd. All rights reserved. (AU)

• FAPESP's process: 15/16157-1 - Influence of maternal vaccination with Tdap on children immune response
• Grantee: Euclides Ayres de Castilho
• Support Opportunities: Regular Research Grants