| Full text | |
| Author(s): |
Listik, Eduardo
[1]
;
Marques Gaschler, Juliana Azevedo
[2]
;
Matias, Murilo
[2]
;
Neuppmann Feres, Murilo Fernando
[3]
;
Toma, Leny
[1]
;
Raphaelli Nahas-Scocate, Ana Carla
[2]
Total Authors: 6
|
| Affiliation: | [1] Univ Fed Sao Paulo, Dept Bioquim, Rua Tres Maio 100, POB 04044-020, Sao Paulo - Brazil
[2] Univ Guarulhos, Dept Ortodontia, Praca Tereza Cristina 229, POB 07023-070, Guarulhos, SP - Brazil
[3] Univ Sao Paulo, Dept Clin Infantil, Ave Cafe, Subsetor Oeste 11 N-11, Ribeirao Preto, SP - Brazil
Total Affiliations: 3
|
| Document type: | Review article |
| Source: | Carbohydrate Polymers; v. 225, DEC 1 2019. |
| Web of Science Citations: | 0 |
| Abstract | |
Proteoglycans (PGs) are proteins which are vital components located in the extracellular matrix, cell surface or intracellular granules. They are linked to polysaccharides called glycosaminoglycans. There are several aspects associated with PGs, such as cell signaling and organization of the extracellular matrix (ECM), making them pivotal participants in many tissue compositions. In teeth, PGs also play an essential role, as many of its components have elaborate ECM structures. However, lack of information on how PGs constitute the various tissues of the tooth and on their roles makes it difficult to elicit the major importance associated with this class of proteins. This review seeks to detail how proteoglycans are involved in many aspects of tooth organization and development, and as far as we are concerned, this has not been performed yet. We have also exemplified the participation of small leucine-rich proteoglycans, a special class of PGs seen in dental trauma cases. (AU) | |
| FAPESP's process: | 16/18066-6 - The role of proteoglycan´s microdomains-6-O-sulfated in tumor biology and tissues. |
| Grantee: | Leny Toma |
| Support Opportunities: | Regular Research Grants |