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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The molecular clock in the skin, its functionality, and how it is disrupted in cutaneous melanoma: a new pharmacological target?

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Monteiro de Assis, Leonardo Vinicius [1] ; Moraes, Maria Nathalia [1, 2] ; de Lauro Castrucci, Ana Maria [1]
Total Authors: 3
[1] Univ Sao Paulo, Inst Biosci, Dept Physiol, Lab Comparat Physiol Pigmentat, Trav 14, 101, BR-05508090 Sao Paulo - Brazil
[2] Univ Anhembi Morumbi, Sch Hlth Sci, Sao Paulo - Brazil
Total Affiliations: 2
Document type: Review article
Source: CELLULAR AND MOLECULAR LIFE SCIENCES; v. 76, n. 19, p. 3801-3826, OCT 2019.
Web of Science Citations: 0

The skin is the interface between the organism and the external environment, acting as its first barrier. Thus, this organ is constantly challenged by physical stimuli such as UV and infrared radiation, visible light, and temperature as well as chemicals and pathogens. To counteract the deleterious effects of the above-mentioned stimuli, the skin has complex defense mechanisms such as: immune and neuroendocrine systems; shedding of epidermal squamous layers and apoptosis of damaged cells; DNA repair; and pigmentary system. Here we have reviewed the current knowledge regarding which stimuli affect the molecular clock of the skin, the consequences to skin-related biological processes and, based on such knowledge, we suggest some therapeutic targets. We also explored the recent advances regarding the molecular clock disruption in melanoma, its impact on the carcinogenic process, and its therapeutic value in melanoma treatment. (AU)

FAPESP's process: 12/50214-4 - Biological clock setting by light and temperature: phylogenetic aspects
Grantee:Ana Maria de Lauro Castrucci
Support type: Research Projects - Thematic Grants
FAPESP's process: 18/14728-0 - Melanopsin as the UVA photoreceptor and its relationship with pigmentation, DNA repair, biological clock and components of the HPA axis. a novel pharmacological target?
Grantee:Ana Maria de Lauro Castrucci
Support type: Regular Research Grants