Acute effect of high-intensity interval training on metabolic and inflammatory markers in obese and overweight adolescents: Pilot study

Author(s)

Monteiro, Paula Alves ^{[1, 2]} ; Freitas Junior, Ismael Forte ^[1] ; Zagatto, Alessandro Moura ^[3] ; Jabur Ribeiro, Jose Procopio ^[4] ; Cabral-Santos, Carolina ^[2] ; Inoue, Daniela Sayuri ^[2] ; Gerosa-Neto, Jose ^[5] ; Lira, Fabio Santos ^[2]

Affiliation

^[1] Sao Paulo State Univ UNESP, Dept Phys Educ, Sch Technol & Sci, Ctr & Prescript Motor Act Lab, Postgrad Program Mo, Presidente Prudente - Brazil

^[2] Sao Paulo State Univ UNESP, Dept Phys Educ, Sch Technol & Sci, Exercise & Immunometab Res Grp, Postgrad Program M, Presidente Prudente - Brazil

^[3] Sao Paulo State Univ UNESP, Sch Technol & Sci, Dept Phys Educ, Lab Physiol & Human Performance FAFIDE, Postgrad P, Bauru - Brazil

^[4] Inst Radiol Presidente Prudente, Sao Paulo - Brazil

^[5] Univ Ctr Maringa UNICESUMAR, Dept Phys Educ, Maringa, Parana - Brazil

• Document type: Journal article
• Source: European Journal of Inflammation; v. 17, SEP 2019.
• Web of Science Citations: 0

Abstract

It is still unclear whether a high-intensity interval exercise (HIIE) protocol is effective for promoting anti-inflammatory and anti-atherogenic responses. The objective of this study was to analyze the acute effects of HIIE on inflammatory and metabolic responses in obese and overweight girls and boys. Initially, the body composition of 19 sedentary volunteers was evaluated. The participants completed an interval experimental run on a treadmill (2:1 min at 95% maximum velocity, totaling similar to 3 km) and blood samples were collected at rest and immediately after the exercise protocol. Serum was analyzed for interleukins 6 and 10 (IL-6 and IL-10), tumor necrosis factor-alpha (TNF-alpha), cortisol, glucose, triacylglycerol (TG), non-esterified fatty acid (NEFA), plasminogen activator inhibitor-1 (PAI-1), and the lipoprotein profile. Under baseline conditions, the groups of boys and girls exhibited differences in the anthropometry measures for fat-free mass (p = 0.011), gynoid fat (p = 0.002), visceral fat (p = 0.004), and glucose (p = 0.031). After the exercise session, cholesterol, glucose, NEFA, PAI-1, IL-10, and TNF-alpha did not demonstrate effects for time, group, or interaction under the different conditions. Cortisol (F = 9.018; p = 0.008; partial eta(2) = 0.347), TG (F = 25.189; p < 0.0001; partial eta(2) = 0.597), and IL-6 levels (F = 6.543; p = 0.020; partial eta(2) = 0.278) showed an effect for time. In conclusion, our results demonstrated that HIIE promoted an immune-endocrine response, increasing cortisol and IL-6 levels immediately after the exercise protocol in overweight and obese girls. (AU)

• FAPESP's process: 15/26148-0 - Role of toll like receptor 4 (TLR-4) in lipolytic response mediated by acute exhaustive exercise
• Grantee: Carolina Cabral Santos
• Support Opportunities: Scholarships in Brazil - Doctorate