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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Addition of phosphates and chlorhexidine to resin-modified MTA materials

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Author(s):
Vitti, Rafael Pino [1] ; Pacheco, Rafael Rocha [2] ; Nogueira Leal Silva, Emmanuel Joao [3] ; Prati, Carlo [4] ; Gandolfi, Maria Giovanna [5] ; Piva, Evandro [6] ; Ogliari, Fabricio Aulo [7] ; Zanchi, Cesar Henrique [6] ; Coelho Sinhoreti, Mario Alexandre [8]
Total Authors: 9
Affiliation:
[1] Univ Taubate, Sch Dent, Dept Prosthodont, Sao Paulo - Brazil
[2] Univ Detroit Mercy, Sch Dent, Dept Restorat Dent, Detroit, MI 48221 - USA
[3] Grande Rio Univ, Sch Dent, Dept Endodont, Rio De Janeiro - Brazil
[4] Univ Bologna, Sch Dent, Dept Biomed & NeuroMotor Sci, Bologna - Italy
[5] Univ Bologna, Sch Dent, Lab Biomat & Oral Pathol, Bologna - Italy
[6] Univ Fed Pelotas, Sch Dent, Dept Operat Dent, Pelotas, RS - Brazil
[7] Univ Fed Pelotas, Sch Mat Engn, Dept Organ Chem, Pelotas, RS - Brazil
[8] Univ Estadual Campinas, Piracicaba Dent Sch, Dept Restorat Dent, Sao Paulo - Brazil
Total Affiliations: 8
Document type: Journal article
Source: JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS; v. 107, n. 6, p. 2195-2201, AUG 2019.
Web of Science Citations: 0
Abstract

To evaluate the properties of experimental mineral trioxide aggregate (MTA) resin-modified materials for root-end filling procedures, varying their compositions regarding the addition of hydroxiapatite (HA) or dicalcium phosphate dihydrate, with or without chlorhexidine digluconate. White MTA (Angelus, Londrina, Brazil) was used as a reference material. Degree of conversion (DC) was evaluated by Fourier transformed infrared (FTIr) spectroscopy (n = 5). Flowability (n = 3) and radiopacity (n = 3) were evaluated following ISO 6876:2001 methods. For splitting tensile strength analysis, cylindrical samples (n = 10) were subjected to compressive load using a universal testing machine (Instron Corporation, Norwood, MA). Water sorption and solubility tests were performed according to ISO 4049:2009 methods. Calcium ion release and pH analysis (n = 10) were evaluated using a pH meter (Orion, Watsonville, CA). Cytotoxicity (n = 8) of materials extracts was evaluated as cell viability percentage. Statistical analysis was performed using Kolmogorov-Smirnov for normal distribution and data was subjected to one-way ANOVA and Tukey test (a = 0.05). Addition of chlorhexidine digluconate reduced DC mean values for experimental materials (<50%). White MTA demonstrated lower flowability (5.3 mm) and higher radiopacity (9.8 mm Al), splitting tensile strength (9.1 MPa), solubility (8.2 mu g/mm(3)), calcium ion release (similar to 26.5 ppm), cytotoxicity (55.2%), and pH mean values (10.8), when compared to experimental materials. All groups demonstrated a decrease in calcium release (<85%) and pH (<13%). Formulation containing HA demonstrated similar pH values after 28 days when compared to white MTA. Evaluated experimental resin-modified MTA based materials without chlorhexidine digluconate showed satisfactory results for all physicochemical properties tested and cytotoxicity. (c) 2019 Wiley Periodicals, Inc. (AU)

FAPESP's process: 12/25034-2 - Development of endodontic sealers based on MTA
Grantee:Rafael Pino Vitti
Support Opportunities: Scholarships in Brazil - Post-Doctoral