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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Angiotensin II type 2 receptor mediates high fat diet-induced cardiomyocyte hypertrophy and hypercholesterolemia

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Lima, Vanessa M. [1] ; Lino, Caroline A. [1] ; Senger, Nathalia [1] ; Silva, Tabatha de Oliveira [1] ; Fonseca, Renata I. B. [1] ; Bader, Michael [2] ; Santos, Robson A. S. [3] ; Donato Junior, Jose [4] ; Barreto-Chaves, Maria Luiza M. [1] ; Diniz, Gabriela P. [1]
Total Authors: 10
[1] Univ Sao Paulo, Inst Biomed Sci, Dept Anat, Sao Paulo - Brazil
[2] Max Delbruck Ctr Mol Med, Berlin - Germany
[3] Univ Fed Minas Gerais, Dept Physiol & Biophys, Belo Horizonte, MG - Brazil
[4] Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, Sao Paulo - Brazil
Total Affiliations: 4
Document type: Journal article
Source: Molecular and Cellular Endocrinology; v. 498, DEC 1 2019.
Web of Science Citations: 0

Obesity is the major risk factor for several cardiovascular and metabolic disorders. Previous studies reported that deletion of Angiotensin II type 2 receptor (AT2R) protects against metabolic dysfunctions induced by high fat (HF) diet. However, the role of AT2R in obesity-induced cardiac hypertrophy remains unclear. Male AT2R knockout (AT2RKO) and wild type (AT2RWT) mice were fed with control or HF diet for 10 weeks. HF diet increased cardiac expression of AT2R in obese mice. Deletion of AT2R did not affect body weight gain, glucose intolerance and fat mass gain induced by HF feeding. However, loss of AT2R prevented HF diet-induced hypercholesterolemia and cardiac remodeling. Mechanistically, we found that pharmacological inhibition or knockdown of AT2R prevented leptin-induced cardiomyocyte hypertrophy in vitro. Collectively, our results suggest that AT2R is involved in obesity-induced cardiac hypertrophy. (AU)

FAPESP's process: 15/21859-5 - Role of microRNA-22 in the development of cardiac and metabolic alterations induced by high fat diet
Grantee:Gabriela Placoná Diniz
Support type: Regular Research Grants
FAPESP's process: 18/10338-2 - Role of microRNA-22 in differentiation of brown adipocytes and in browning of white adipose tissue
Grantee:Gabriela Placoná Diniz
Support type: Regular Research Grants