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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Neuropathological lesions in the very old: results from a large Brazilian autopsy study

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Author(s):
Suemoto, Claudia K. [1] ; Leite, Renata E. P. [1] ; Ferretti-Rebustini, Renata E. L. [2] ; Rodriguez, Roberta D. [3] ; Nitrini, Ricardo [3] ; Pasqualucci, Carlos A. [4] ; Jacob-Filho, Wilson [1] ; Grinberg, Lea T. [5, 4]
Total Authors: 8
Affiliation:
[1] Univ Sao Paulo, Div Geriatr, Med Sch, Sao Paulo - Brazil
[2] Univ Sao Paulo, Dept Med Surg Nursing, Sch Nursing, Sao Paulo - Brazil
[3] Univ Sao Paulo, Dept Neurol, Med Sch, Sao Paulo - Brazil
[4] Univ Sao Paulo, Dept Pathol, Med Sch, Sao Paulo - Brazil
[5] Univ Calif San Francisco, Dept Neurol, Memory & Aging Ctr, San Francisco, CA - USA
Total Affiliations: 5
Document type: Journal article
Source: Brain Pathology; v. 29, n. 6, p. 771-781, NOV 2019.
Web of Science Citations: 1
Abstract

Objective To compare neuropathological correlates of cognitive impairment between very old and younger individuals from a Brazilian clinicopathological study. Methods We assessed the frequency of neuropathological lesions and their association with cognitive impairment (Clinical Dementia Rating scale >= 0.5) in the 80 or over age group compared to younger participants, using logistic regression models adjusted for sex, race and education. Results Except for infarcts and siderocalcinosis, all neuropathological lesions were more common in the 80 or over age group (n = 412) compared to 50-79 year olds (n = 677). Very old participants had more than twice the likelihood of having >= 2 neuropathological diagnoses than younger participants (OR = 2.66, 95% CI = 2.03-3.50). Neurofibrillary tangles, infarcts and hyaline arteriolosclerosis were associated with cognitive impairment in the two age groups. Siderocalcinosis was associated with cognitive impairment in the younger participants only, while Lewy body disease was associated with cognitive impairment in the very old only. In addition, we found that the association of infarcts and multiple pathologies with cognitive impairment was attenuated in very old adults (Infarcts: P for interaction = 0.04; and multiple pathologies: P = 0.05). However, the predictive value for the aggregate model with all neuropathological lesions showed similar discrimination in both age groups {[}Area under Receiver Operating Characteristic curve (AUROC) = 0.778 in younger participants and AUROC = 0.765 in the very old]. Conclusion and relevance Despite a higher frequency of neuropathological findings in the very old group, as found in studies with high-income populations, we found attenuation of the effect of infarcts rather than neurofibrillary tangles and plaques as reported previously. (AU)

FAPESP's process: 06/55318-1 - Nosological diagnosis of dementia in a Brazilian population
Grantee:Ricardo Nitrini
Support Opportunities: Regular Research Grants
FAPESP's process: 09/09134-4 - The cognitive reserve in a population with low educational attainment
Grantee:Wilson Jacob Filho
Support Opportunities: Regular Research Grants