St Josephs Hosp, Trauma Res, Thermoregulat & Syst Inflammat Lab FeverLab, Phoenix, AZ - USA
 Fed Univ ABC, Undergrad Program Neurosci, Sao Bernardo Do Campo - Brazil
 Fed Univ ABC, Ctr Math Comp & Cognit, Sao Bernardo Do Campo - Brazil
 Fed Univ ABC, Ctr Nat & Human Sci, Sao Bernardo Do Campo - Brazil
Total Affiliations: 6
OCT 20 2019.
Web of Science Citations:
Animal models have promoted meaningful contribution to science including Alzheimer's disease (AD) research. Several animal models for AD have been used, most of them related to genetic mutations observed in familial AD. However, sporadic form of AD, also named late-onset is the most frequent form of the disease, which is multifactorial, being influenced by genetic, environmental and lifestyle factors. Here, we describe a protocol of an AD-like pathology of the sporadic form using Wistar rats by a single bilateral intracerebroventricular (icy) injection of streptozotocin (STZ, 2 mg/kg). Icy injection of STZ induces brain resistance to insulin and other pathological alterations related to those observed in AD, such as cognitive impairment and accumulation of phosphorylated tau protein and beta-amyloid in the brain. Thus, icy injection of STZ is a useful tool to investigate the pathological mechanisms and the metabolic alterations involved in AD and to propose new therapeutic approaches and neuroprotective drugs. (AU)