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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Study of mastoparan analog peptides against Candida albicans and safety in zebrafish embryos (Danio rerio)

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Author(s):
Galeane, Mariana C. [1] ; Gomes, Paulo C. [1] ; Singulani, Junya de L. [1] ; de Souza, Bibiana M. [2] ; Palma, Mario S. [2] ; Mendes-Giannini, Maria J. S. [1] ; Almeida, Ana M. F. [1]
Total Authors: 7
Affiliation:
[1] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, Dept Clin Anal, BR-14800903 Araraquara, SP - Brazil
[2] Sao Paulo State Univ UNESP, CEIS LSBZ, Dept Biol, Inst Biosci, BR-13506900 Rio Claro, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: FUTURE MICROBIOLOGY; v. 14, n. 13, p. 1087-1097, SEP 2019.
Web of Science Citations: 0
Abstract

Aim: In this work, mastoparan analog peptides from wasp venom were tested against Candida albicans and safety assays were performed using cell culture and model zebrafish. Materials \& methods: Minimal inhibitory concentration was determined and toxicity was performed using human skin keratinocyte and embryo zebrafish. Also, permeation of peptides through embryo chorion was performed. Results: The peptides demonstrated anti-C. albicans activity, with low cytotoxicity and nonteratogenicity in Danio rerio. The compounds had different permeation through chorion, suggesting that this occurs due to modifications in their amino acid sequence. Conclusion: The results showed that the studied peptides can be used as structural study models for novel potential antifungal agents. (AU)

FAPESP's process: 17/06658-9 - Platform for antifungal development in a nanostructured lipid system aiming at efficacy and safety in alternative animal models
Grantee:Junya de Lacorte Singulani
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 16/11836-0 - SELECTION OF THERAPEUTIC TARGETS AND/OR BIOMARKERS FROM GLOBAL RESPONSE TRANSCRIPTIONAL OF ALVEOLAR MACROPHAGES INFECTED BY H. capsulatum BIOFILMS
Grantee:Ana Marisa Fusco Almeida
Support type: Regular Research Grants