ADP-ribosylation: from molecular mechanisms to human disease

Nicolas C. Hoch; Luis M. Polo

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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

ADP-ribosylation: from molecular mechanisms to human disease

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Author(s):	Nicolas C. Hoch ^[1] ; Luis M. Polo Total Authors: 2
Affiliation:	^[1] Universidade de São Paulo. Departamento de Bioquímica. Instituto de Química - Brasil Total Affiliations: 2
Document type:	Journal article
Source:	GENETICS AND MOLECULAR BIOLOGY; v. 43, n. 1 2019-12-13.
Abstract
Abstract Post-translational modification of proteins by ADP-ribosylation, catalysed by poly (ADP-ribose) polymerases (PARPs) using NAD+ as a substrate, plays central roles in DNA damage signalling and repair, modulates a range of cellular signalling cascades and initiates programmed cell death by parthanatos. Here, we present mechanistic aspects of ADP-ribose modification, PARP activation and the cellular functions of ADP-ribose signalling, and discuss how this knowledge is uncovering therapeutic avenues for the treatment of increasingly prevalent human diseases such as cancer, ischaemic damage and neurodegeneration. (AU)

FAPESP's process:	18/18007-5 - Protein ADP-ribosylation: DNA damage signalling and impacts on human health
Grantee:	Nicolas Carlos Hoch
Support Opportunities:	Research Grants - Young Investigators Grants

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