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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

ADP-ribosylation: from molecular mechanisms to human disease

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Hoch, Nicolas C. [1] ; Polo, Luis M. [2, 3]
Total Authors: 2
[1] Univ Sao Paulo, Inst Quim, Dept Bioquim, Av Prof Lineu Prestes 748, BR-05508000 Sao Paulo, SP - Brazil
[2] Univ Sussex, Sch Life Sci, Genome Damage & Stabil Ctr, Canc Res UK DNA Repair Enzymes Grp, Brighton, E Sussex - England
[3] Consejo Nacl Invest Cient & Tecn, Inst Histol & Embryol Mendoza, Mendoza - Argentina
Total Affiliations: 3
Document type: Review article
Source: GENETICS AND MOLECULAR BIOLOGY; v. 43, n. 1, 1 2020.
Web of Science Citations: 0

Post-translational modification of proteins by ADP-ribosylation, catalysed by poly (ADP-ribose) polymerases (PARPs) using NAD(+) as a substrate, plays central roles in DNA damage signalling and repair, modulates a range of cellular signalling cascades and initiates programmed cell death by parthanatos. Here, we present mechanistic aspects of ADP-ribose modification, PARP activation and the cellular functions of ADP-ribose signalling, and discuss how this knowledge is uncovering therapeutic avenues for the treatment of increasingly prevalent human diseases such as cancer, ischaemic damage and neurodegeneration. (AU)

FAPESP's process: 18/18007-5 - Protein ADP-ribosylation: DNA damage signalling and impacts on human health
Grantee:Nicolas Carlos Hoch
Support type: Research Grants - Young Investigators Grants