ADP-ribosylation: from molecular mechanisms to human disease

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Author(s):	Hoch, Nicolas C. ^[1] ; Polo, Luis M. ^{[2, 3]} Total Authors: 2
Affiliation:	^[1] Univ Sao Paulo, Inst Quim, Dept Bioquim, Av Prof Lineu Prestes 748, BR-05508000 Sao Paulo, SP - Brazil ^[2] Univ Sussex, Sch Life Sci, Genome Damage & Stabil Ctr, Canc Res UK DNA Repair Enzymes Grp, Brighton, E Sussex - England ^[3] Consejo Nacl Invest Cient & Tecn, Inst Histol & Embryol Mendoza, Mendoza - Argentina Total Affiliations: 3
Document type:	Review article
Source:	GENETICS AND MOLECULAR BIOLOGY; v. 43, n. 1, 1 2020.
Web of Science Citations:	0
Abstract
Post-translational modification of proteins by ADP-ribosylation, catalysed by poly (ADP-ribose) polymerases (PARPs) using NAD(+) as a substrate, plays central roles in DNA damage signalling and repair, modulates a range of cellular signalling cascades and initiates programmed cell death by parthanatos. Here, we present mechanistic aspects of ADP-ribose modification, PARP activation and the cellular functions of ADP-ribose signalling, and discuss how this knowledge is uncovering therapeutic avenues for the treatment of increasingly prevalent human diseases such as cancer, ischaemic damage and neurodegeneration. (AU)

FAPESP's process:	18/18007-5 - Protein ADP-ribosylation: DNA damage signalling and impacts on human health
Grantee:	Nicolas Carlos Hoch
Support type:	Research Grants - Young Investigators Grants