Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Genome and transcriptome analyses of Leishmania spp.: opening Pandora's box

Full text
Author(s):
Cruz, Angela Kaysel [1] ; Freitas-Castro, Felipe [1]
Total Authors: 2
Affiliation:
[1] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Cell & Mol Biol, Ribeirao Preto - Brazil
Total Affiliations: 1
Document type: Review article
Source: Current Opinion in Microbiology; v. 52, p. 64-69, DEC 2019.
Web of Science Citations: 0
Abstract

In the last 30 years, significant advances in genetic manipulation tools along with complete genome and transcriptome sequencing have advanced our understanding of the biology of Leishmania parasites and their interplay with the sand fly and mammalian hosts. High-throughput sequencing in association with CRISPR/Cas9 have prepared the ground for significant advances. Given the richness of the progress made over the last decade, in this article, we focused on the most recent contributions of genome-wide and transcriptome analyses of Leishmania spp., which permit the comparison of life cycle stages, the evaluation of different strains and species in their natural niches and in the field and the simultaneously comparison of the gene expression profiles of parasites and hosts. (AU)

FAPESP's process: 13/50219-9 - Studying the control of gene expression in Leishmania: post-translational modification, non coding RNAs, cis-elements and gene amplification
Grantee:Angela Kaysel Cruz
Support Opportunities: Research Projects - Thematic Grants