Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The toxicity of silver nanomaterials (NM 300K) is reduced when combined with N-Acetylcysteine: Hazard assessment on Enchytraeus crypticus

Full text
Author(s):
Mendonca, Monique C. P. [1, 2] ; Rodrigues, Natalia P. [2] ; Scott-Fordsmand, Janeck J. [3] ; de Jesus, Marcelo Bispo [1] ; Amorim, Monica J. B. [2]
Total Authors: 5
Affiliation:
[1] Univ Estadual Campinas, Inst Biol, Dept Biochem & Tissue Biol, BR-13083970 Campinas, SP - Brazil
[2] Univ Aveiro, Dept Biol, CESAM, P-3810193 Aveiro - Portugal
[3] Aarhus Univ, Dept Biosci, DK-8600 Silkeborg - Denmark
Total Affiliations: 3
Document type: Journal article
Source: Environmental Pollution; v. 256, JAN 2020.
Web of Science Citations: 1
Abstract

The widespread production and use of silver nanomaterials (AgNMs) in consumer and medical products have been raising environmental concerns. Once in the environment, the soil is one of the major sinks of AgNMs due to e.g. sewage sludge applications, and invertebrates are directly exposed. In this study, we investigate the potential of N-acetylcysteine (NAC) to reduce the toxic effects of Ag NM300 K (and AgNO3) on the soil invertebrate Enchytraeus crypticus. Ag NM300 K induces mortality, reproduction impairment, and avoidance. The addition of NAC to the soil showed a remarkable reduction in the toxicity of Ag, indicating that NAC can act as a detoxifying agent for terrestrial organisms exposed to Ag materials. That the reduction in toxicity likely is caused by thiol groups, was confirmed by GSH and GSSH studies. Identifying the mechanisms and hence alternatives that allow the recovery of contaminated soils is an important mitigation measure to promote environmental safety and reduce the associated risks to human health. Further, it may inform on strategies to implement in safe-by-design industry development. (C) 2019 Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 14/03002-7 - Internalization and intracellular trafficking of nanoparticles: biological activity and nanotoxicological profile
Grantee:Marcelo Bispo de Jesus
Support Opportunities: Research Grants - Young Investigators Grants
FAPESP's process: 17/18867-1 - Toxicological assessment of nanomaterials in soil invertebrate species
Grantee:Monique Culturato Padilha Mendonça
Support Opportunities: Scholarships abroad - Research Internship - Post-doctor