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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Depletion of hypothalamic hypocretin/orexin neurons correlates with impaired memory in a Parkinson's disease animal model

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Author(s):
Oliveira, Luiz M. [1] ; Henrique, Elisandra [2] ; Bustelli, Isabella B. [2] ; Netto, Nelson F. C. [2] ; Moreira, Thiago S. [3] ; Takakura, Ana C. [1] ; Caetano, Ariadiny L. [2]
Total Authors: 7
Affiliation:
[1] Univ Sao Paulo, Inst Biomed Sci, Dept Pharmacol, 1524 Lineu Prestes Ave, BR-05508000 Sao Paulo, SP - Brazil
[2] Santa Casa Sao Paulo Sch Med Sci, Dept Physiol Sci, 61 Dr Cesario Motta Jr St, BR-01221020 Sao Paulo, SP - Brazil
[3] Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, BR-05508000 Sao Paulo, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Experimental Neurology; v. 323, JAN 2020.
Web of Science Citations: 0
Abstract

Parkinson's disease (PD) is a progressive and chronic neurodegenerative disorder characterized by loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) and affects multiple neurotransmission systems such as hypocretin/orexin (HO) release and can lead to cognitive and memory deficits. The HO neurons located in lateral hypothalamus/perifomical area (LH/PeF) are involved with consolidation and memory processes. Here we verified the involvement of HO deficit in learning and memory process in an animal model of PD induced by bilateral intra-striatal injections of 6-hydroxydopamine (6-OHDA). The present study performed a working memory test by object recognition task and spatial memory test using the Morris water maze in control and PD-induced animals after depletion of HO neurons. In addition, our results indicate that HO system in degenerative disorders such as PD may modulate the declarative and spatial memory (assessed by object recognition and Morris water maze tests, respectively). A significant reduction of HO neurons in the LH/PeF and HO degeneration process in the hippocampus (CA1 and dentate gyrus areas) were noticed. Our data suggest that the HO system degeneration could be associated to memory dysfunction in PD. (AU)

FAPESP's process: 17/20420-5 - The role of locus coeruleus (LC) in the spatial memory in a non-motor symptoms of 6-OHDA model of Parkinson's Disease
Grantee:Isabella Bacci Bustelli
Support Opportunities: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 16/23281-3 - Encephalic regions responsible for neuroplasticity observed in respiratory response induced by hypercapnia in a modelo of Parkinson's Disease
Grantee:Ana Carolina Takakura Moreira
Support Opportunities: Regular Research Grants
FAPESP's process: 17/12266-6 - Optogenetic stimulation of pre-Bötzinger complex neurons and the control of breathing in a mice model of Parkinson's disease
Grantee:Luiz Marcelo Oliveira Santos
Support Opportunities: Scholarships abroad - Research Internship - Doctorate
FAPESP's process: 15/23376-1 - Retrotrapezoid nucleus, respiratory chemosensitivity and breathing automaticity
Grantee:Thiago dos Santos Moreira
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 15/18842-3 - Orexinergic and aminergic mechanisms in respiratory control in an animal model of Parkinsons Disease
Grantee:Luiz Marcelo Oliveira Santos
Support Opportunities: Scholarships in Brazil - Doctorate