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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Nandrolone decanoate and resistance exercise affect prostate morphology and hormone receptor interface in adult rats with implications for the aging process

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Author(s):
Gomes, F. de C. [1, 2] ; Chuffa, L. G. de A. [2] ; Favaro, W. J. [3] ; Scarano, W. R. [4] ; de Melo-Neto, J. S. [5, 6] ; Pinheiro, P. F. F. [2] ; Domeniconi, R. F. [2]
Total Authors: 7
Affiliation:
[1] Sao Jose do Rio Preto Med Sch FAMERP, Genet & Mol Biol Res Unit UPGEM, Sao Jose Do Rio Preto, SP - Brazil
[2] Univ Estadual Paulista, Inst Biosci, Dept Anat, UNESP, POB 510, Rubiao Jr S-N, BR-18618970 Botucatu, SP - Brazil
[3] Univ Estadual Campinas, Inst Biol, Dept Struct & Funct Biol, UNICAMP, Campinas, SP - Brazil
[4] Univ Estadual Paulista, Inst Biosci, Dept Morphol, UNESP, Botucatu, SP - Brazil
[5] Fac Med Marilia FAMEMA, Marilia, SP - Brazil
[6] Fed Univ Para UFPA, Inst Hlth Sci, Belem, Para - Brazil
Total Affiliations: 6
Document type: Journal article
Source: ANDROLOGY; v. 8, n. 1, p. 211-220, JAN 2020.
Web of Science Citations: 0
Abstract

Background Nandrolone decanoate (ND) is an anabolic-androgenic steroid, and its indiscriminate use leads to subclinical alterations in the hypothalamic-pituitary-gonadal axis and androgen-dependent organs. Objectives To evaluate the effects of ND, either alone or in combination with resistance exercise (RE), on the levels of sex hormones, converting enzymes, and steroid receptors and the morphology of the ventral prostate (VP) in adult and aged rats. Methods Forty Sprague-Dawley adult and aged rats were divided into four groups each, sedentary and trained with and without ND. The groups received treatments over 8 weeks. Adult animals were sacrificed immediately following treatment completion, while the aged groups were left untreated until 300 days of age. Results Adult and aged animals showed reductions in testosterone levels following the different treatments, and 17 beta-estradiol levels were decreased in the ND-treated groups. The level of 5 alpha-reductase type 2 (5 alpha R2) and aromatase was increased significantly in the prostates of adult animals that performed RE. However, aromatase levels were decreased in the prostates of aged animals that performed RE and were treated with ND, while 5 alpha R2 levels were reduced in aged animals that performed RE without ND treatment. When sex receptors levels were examined, the aged and trained animals presented low androgen receptor (AR) levels. Estrogen receptors (ERs) levels were increased in the prostates of adult animals that received ND. ER beta levels were reduced after treatments in aged animals. The heights of the prostatic epithelium were reduced in all adult treated animals, coinciding with increases in PCNA and PAR4 levels. Discussion ND and RE alter the levels of hormone, converting enzymes, and sex steroid receptors and the morphology of the VP. These effects were observed in both adult and aged rats. Conclusion ND, either with or without RE, during post-puberty stage is able to interfere with the morphophysiology of the prostate. (AU)

FAPESP's process: 13/00649-7 - Histopathological, biochemical and molecular analyzes on the effect of physical exercise and high doses of Nandrolone Deconoate during the post-pubertal on aging rat prostates
Grantee:Fabiana de Campos Gomes
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 13/07203-4 - Histopathological, biochemical and molecular analyzes on the effect of physical exercise and high doses of nandrolone Deconoate during the post-pubertal on aging rat prostates
Grantee:Raquel Fantin Domeniconi
Support Opportunities: Regular Research Grants