Involvement of P2 receptors in hematopoiesis and hematopoietic disorders, and as pharmacological targets

Author(s)

Filippin, Kelly Juliana ^[1] ; de Souza, Kamylla F. S. ^[2] ; de Araujo Junior, Roberto Theodoro ^[2] ; Torquato, Heron Fernandes Vieira ^{[2, 3]} ; Dias, Dhebora Albuquerque ^[1] ; Parisotto, Eduardo Benedetti ^[1] ; Ferreira, Alice Teixeira ^{[4, 5]} ; Paredes-Gamero, Edgar J. ^{[1, 2, 5]}

Affiliation

^[1] Univ Fed Mato Grosso do Sul, Fac Ciencias Farmaceut Alimentos & Nutr, BR-79070900 Campo Grande, MS - Brazil

^[2] Univ Fed Sao Paulo, Dept Bioquim, R Tres Maio 100, BR-04044020 Sao Paulo, SP - Brazil

^[3] Univ Braz Cubas, Ave Francisco Rodrigues Filho 1233, BR-08773380 Mogi Das Cruzes, SP - Brazil

^[4] Univ Fed Sao Paulo, Dept Biofis, R Botucatu 862, BR-04023062 Sao Paulo, SP - Brazil

^[5] Fac Ciencias Farmaceut Alimentos & Nutr FACFAN, Lab Biol Mol & Culturas Celulares, Ave Costa & Silva, S-N Bairro Univ, BR-79070900 Campo Grande, MS - Brazil

• Document type: Review article
• Source: PURINERGIC SIGNALLING; v. 16, n. 1 DEC 2019.
• Web of Science Citations: 1

Abstract

Several reports have shown the presence of P2 receptors in hematopoietic stem cells (HSCs). These receptors are activated by extracellular nucleotides released from different sources. In the hematopoietic niche, the release of purines and pyrimidines in the milieu by lytic and nonlytic mechanisms has been described. The expression of P2 receptors from HSCs until maturity is still intriguing scientists. Several reports have shown the participation of P2 receptors in events associated with modulation of the immune system, but their participation in other physiological processes is under investigation. The presence of P2 receptors in HSCs and their ability to modulate this population have awakened interest in exploring the involvement of P2 receptors in hematopoiesis and their participation in hematopoietic disorders. Among the P2 receptors, the receptor P2X7 is of particular interest, because of its different roles in hematopoietic cells (e.g., infection, inflammation, cell death and survival, leukemias and lymphomas), making the P2X7 receptor a promising pharmacological target. Additionally, the role of P2Y12 receptor in platelet activation has been well-documented and is the main example of the importance of the pharmacological modulation of P2 receptor activity. In this review, we focus on the role of P2 receptors in the hematopoietic system, addressing these receptors as potential pharmacological targets. (AU)

• FAPESP's process: 18/23870-4 - Role of P2X7 purinergic receptor in the regulation of hematopoietic stem cell and myeloid lineage
• Grantee: Alice Teixeira Ferreira
• Support Opportunities: Regular Research Grants