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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Small Particles, Big Effects: The Interplay Between Exosomes and Dendritic Cells in Antitumor Immunity and Immunotherapy

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Author(s):
Benites, Bruno Deltreggia [1] ; Alvarez, Marisa Claudia [1] ; Olalla Saad, Sara Teresinha [1]
Total Authors: 3
Affiliation:
[1] Univ Estadual Campinas, Hematol & Transfus Med Ctr, BR-13083970 Campinas - Brazil
Total Affiliations: 1
Document type: Review article
Source: CELLS; v. 8, n. 12 DEC 2019.
Web of Science Citations: 0
Abstract

Dendritic cells play a fundamental role in the antitumor immunity cycle, and the loss of their antigen-presenting function is a recognized mechanism of tumor evasion. We have recently demonstrated the effect of exosomes extracted from serum of patients with acute myeloid leukemia as important inducers of dendritic cell immunotolerance, and several other works have recently demonstrated the effects of these nanoparticles on immunity to other tumor types as well. The aim of this review was to highlight the recent findings on the effects of tumor exosomes on dendritic cell functions, the mechanisms by which they can lead to tumor evasion, and their manipulation as a possible strategy in cancer treatment. (AU)

FAPESP's process: 17/21801-2 - Predictors of severity and new treatments for bone marrow neoplasias
Grantee:Sara Teresinha Olalla Saad
Support Opportunities: Research Projects - Thematic Grants