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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Choline attenuates inflammatory hyperalgesia activating nitric oxide/cGMP/ATP-sensitive potassium channels pathway

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Author(s):
Kusuda, Ricardo [1] ; Carreira, Eleonora Uchoa [1] ; Ulloa, Luis [2] ; Cunha, Fernando Queiroz [1] ; Kanashiro, Alexandre [3] ; Cunha, Thiago Mattar [1]
Total Authors: 6
Affiliation:
[1] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Pharmacol, Ribeirao Preto - Brazil
[2] Duke Univ, Dept Anesthesiol, Ctr Perioperat Organ Protect, Durham, NC 27710 - USA
[3] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Neurosci & Behav, Ribeirao Preto - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Brain Research; v. 1727, JAN 15 2020.
Web of Science Citations: 0
Abstract

New findings on neural regulation of immunity are allowing the design of novel pharmacological strategies to control inflammation and nociception. Herein, we report that choline, a 7-nicotinic acetylcholine receptor (alpha 7nAChRs) agonist, prevents carrageenan-induced hyperalgesia without affecting inflammatory parameters (neutrophil migration or cytokine/chemokines production) or inducing sedation or even motor impairment. Choline also attenuates prostaglandin-E-2 (PGE(2))-induced hyperalgesia via alpha 7nAChR activation and this antinociceptive effect was abrogated by administration of LNMMA (a nitric oxide synthase inhibitor), ODQ (an inhibitor of soluble guanylate cyclase; cGMP), and glibenclamide (an inhibitor of ATP-sensitive potassium channels). Furthermore, choline attenuates long-lasting Complete Freunds Adjuvant and incision-induced hyperalgesia suggesting its therapeutic potential to treat pain in rheumatoid arthritis or post-operative recovery, respectively. Our results suggest that choline modulates inflammatory hyperalgesia by activating the nitric oxide/cGMP/ATP-sensitive potassium channels without interfering in inflammatory events, and could be used in persistent pain conditions. (AU)

FAPESP's process: 12/23846-0 - Role of succinate/GPR91 signaling in the physiopathology of neuropathic pain
Grantee:Ricardo Kusuda
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 13/08216-2 - CRID - Center for Research in Inflammatory Diseases
Grantee:Fernando de Queiroz Cunha
Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
FAPESP's process: 11/20343-4 - Antiinflammatory cholinergic pathway: the role of neuroimmunomodulation in the control of inflammatory response
Grantee:Alexandre Kanashiro
Support Opportunities: Research Grants - Young Investigators Grants
FAPESP's process: 10/16823-8 - Investigation of the mechanisms involved in the analgesic effect of choline.
Grantee:Eleonora Uchôa Carreira
Support Opportunities: Scholarships in Brazil - Scientific Initiation