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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Technetium-99m-dimercaptosuccinic acid renal scintigraphy and single photon emission computed tomography/computed tomography in patients with sickle cell disease

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Author(s):
Ramos, Celso Dario [1] ; Onusic, Daniel Massaro [1] ; Brunetto, Sergio Querino [2] ; Amorim, Barbara Juarez [1] ; Souza, Thiago Ferreira [1] ; Olalla Saad, Sara Teresinha [3] ; Lopes Lima, Mariana da Cunha [1]
Total Authors: 7
Affiliation:
[1] Univ Estadual Campinas, Div Nucl Med, Dept Radiol, Zeferino Vaz Ave S-N, POB 6149, BR-13080000 Campinas - Brazil
[2] Univ Estadual Campinas, Hematol Div, Dept Internal Med, Campinas - Brazil
[3] Univ Estadual Campinas, Ctr Biomed Engn CEB, Campinas - Brazil
Total Affiliations: 3
Document type: Journal article
Source: NUCLEAR MEDICINE COMMUNICATIONS; v. 40, n. 11, p. 1158-1165, NOV 2019.
Web of Science Citations: 0
Abstract

Purpose Sickle cell disease (SCD) is a common hematologic hereditary disorder characterized by vaso-occlusive episodes affecting multiple organs, and substantially alters renal structure and function. We aimed to evaluate the utility of renal scintigraphy and single photon emission computed tomography/computed tomography (SPECT/CT) with technetium-99m-dimercaptosuccinic acid (Tc-99m-DMSA) in adult patients with SCD and no clinical evidence of renal insufficiency. Materials and methods Twenty-six patients (16 female) aged 23-58 years with SCD and no clinical evidence of renal insufficiency were prospectively studied. Planar and SPECT/CT images were, respectively, obtained after 3 and 4 hours of the injection of 110-180 MBq of Tc-99m-DMSA. The relative radiopharmaceutical uptake and renal length were, respectively, determined using SPECT and CT images. Planar and SPECT/CT images were visually analyzed to identify focal areas of Tc-99m-DMSA reduced uptake and anatomical deformities of the kidneys. Results Focal areas of reduced Tc-99m-DMSA uptake with an image aspect of renal scars or inflammation were present in 21/26 patients (81%). In 11/21 (52%) of these patients, the cortical lesions were clearly identified only on SPECT images. Prominent renal columns were observed in 17/26 (65%) patients. The left kidney tended to be more affected than the right kidney. Most patients had enlarged kidneys. Conclusion Tc-99m-DMSA scintigraphy and SPECT/CT identify renal lesions possible related to renal infarcts or infections in most adult patients with SCD and no clinical evidence of renal insufficiency. Prominent renal columns and increased renal size tend to occur in most of these patients. (AU)

FAPESP's process: 12/51833-0 - SPECT/CT with 99 Tc-DMSA in patients with sickle cell anemia: images and quantification of renal tubular function and compared with glomerular function
Grantee:Celso Darío Ramos
Support Opportunities: Regular Research Grants