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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Oral melanomas in HIV-positive patients: Report of two cases and review of the literature

Full text
Author(s):
de Lima Morais, Thayna Melo [1] ; Soares, Ciro Dantas [1] ; Costa Wanderley, Arthur Eric [2] ; Rosa de Oliveira, Catarina Rodrigues [2] ; Beder Ribeiro, Camila Maria [2] ; de Almeida, Oslei Paes [1] ; Freire de Carvalho, Maria Goretti [3] ; Soares Ferreira, Sonia Maria [2]
Total Authors: 8
Affiliation:
[1] Univ Estadual Campinas, Piracicaba Dent Sch, Dept Oral Diag, Oral Pathol, Campinas - Brazil
[2] Cesmac, Sch Dent, Oral Pathol, Maceio, Alagoas - Brazil
[3] Private Pathol Serv, Natal, RN - Brazil
Total Affiliations: 3
Document type: Letter
Source: Oral Oncology; v. 101, FEB 2020.
Web of Science Citations: 0
Abstract

Oral melanoma in HIV-positive patients is exceedingly rare, with only two cases reported in the literature published in English. Herein, we report two additional cases of oral melanomas which occurred as oral masses in the upper gingiva and hard palate in 35- and 27-year-old HIV-positive women. Significant thrombocytopenia, anemia, reduced CD4 cells, and high HIV load occurred in both patients. Microscopically, the lesions showed a variable proliferation of fusiform and epithelioid-pigmented cells, with cellular pleomorphism and high mitotic index. The diagnosis of melanoma was supported by positive immunoreactivity for S-100, MelanA, and HMB-45. Both cases had an unfavorable outcome, and the patients died a few months after the initial diagnosis. Because of its rarity, oral melanoma occurring in HIV-positive patients can pose problems in diagnosis and should be clinically distinguished from Kaposi's sarcoma, which is more common in the context of the immunodeficiency syndrome. (AU)

FAPESP's process: 17/16102-8 - Akt, COX-2, RUNX1 and MMPs expression in metastatic melanomas
Grantee:Jacks Jorge Junior
Support Opportunities: Regular Research Grants
FAPESP's process: 15/25905-1 - Akt, COX-2, RUNX1 and MMPs expression in metastatic melanomas and Biotechnology prospection of molecules with antineoplastic activity
Grantee:Ciro Dantas Soares
Support Opportunities: Scholarships in Brazil - Doctorate