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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Repercussions of adjuvant-induced arthritis on body composition, soleus muscle, and heart muscle of rats

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Author(s):
L.M. Pita [1] ; M.A. Spadella [2] ; M.C. Montenote [3] ; P.B. Oliveira [4] ; A.B. Chies [5]
Total Authors: 5
Affiliation:
[1] Faculdade de Medicina de Marília. Laboratório de Farmacologia - Brasil
[2] Faculdade de Medicina de Marília. Laboratório de Embriologia Humana - Brasil
[3] Instituto de Biociências de Botucatu. Departamento de Farmacologia - Brasil
[4] Faculdade de Medicina de Marília. Laboratório de Farmacologia - Brasil
[5] Faculdade de Medicina de Marília. Laboratório de Farmacologia - Brasil
Total Affiliations: 5
Document type: Journal article
Source: Brazilian Journal of Medical and Biological Research; v. 53, n. 3 2020-03-02.
Abstract

This study investigated the repercussions of adjuvant-induced arthritis (AIA) on body composition and the structural organization of the soleus and cardiac muscles, including their vascularization, at different times of disease manifestation. Male rats were submitted to AIA induction by intradermal administration of 100 μL of Mycobacterium tuberculosis (50 mg/mL), in the right hind paw. Animals submitted to AIA were studied 4 (AIA4), 15 (AIA15), and 40 (AIA40) days after AIA induction as well as a control group of animals not submitted to AIA. Unlike the control animals, AIA animals did not gain body mass throughout the evolution of the disease. AIA reduced food consumption, but only on the 40th day after induction. In the soleus muscle, AIA reduced the wet mass in a time-dependent manner but increased the capillary density by the 15th day and the fiber density by both 15 and 40 days after induction. The diameter of the soleus fiber decreased from the 4th day after AIA induction as well as the capillary/fiber ratio, which was most evident on the 40th day. Moreover, AIA induced slight histopathological changes in the cardiac muscle that were more evident on the 15th day after induction. In conclusion, AIA-induced changes in body composition as well as in the soleus muscle fibers and vasculature have early onset but are more evident by the 15th day after induction. Moreover, the heart may be a target organ of AIA, although less sensitive than skeletal muscles. (AU)

FAPESP's process: 16/08450-3 - Influence of testosterone in the vascular changes promoted by adjuvant-induced arthritis that involves angiotensin II
Grantee:Agnaldo Bruno Chies
Support Opportunities: Regular Research Grants