Lima, Thaina A.
Machini, M. Teresa
Total Authors: 3
 Univ Sao Paulo, Inst Chem, Dept Biochem, Av Prof Lineu Prestes 748, POB 26077, BR-05513970 Sao Paulo, SP - Brazil
 Pontifical Catholic Univ Campinas PUC Campinas, Postgrad Program Hlth Sci, Ctr Life Sci, R Prof Dr Euryclides de Jesus Zerbini 1516, BR-13087571 Campinas, SP - Brazil
Total Affiliations: 2
Web of Science Citations:
Surfactins are important lipopeptides produced by Bacillus subtilis that present strong surface activity. These biosurfactants find applications in various fields, from environmental remediation to medicine. The use of surfactins in remediation is hampered by production costs; the medical applications are also reframed because of the hemolytic activity of the cyclic peptide. To reduce costs and working time, the present work focused on the design, chemical synthesis and characterization of simple linear variants of surfactins having only l-amino acids and lauric acid at the N-terminal. Carboxyl-free and amidated analogues with negative, null and positive net charges at physiological pH were successfully obtained. The synthetic isoforms of surfactins showed high surface activity and ability to inhibit both growth and adhesion of Streptococcus mutans cells. Therefore, these properties make these low-cost synthetic peptides relevant and promising new compounds for science, industry and, mainly, dental care. (AU)