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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The effectiveness of photobiomodulation in the management of temporomandibular pain sensitivity in rats: behavioral and neurochemical effects

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Author(s):
Rodrigues, Alex de Freitas [1, 2] ; Martins, Daniel de Oliveira [1] ; Chacur, Marucia [1] ; Luz, Joao Gualberto C. [2]
Total Authors: 4
Affiliation:
[1] Univ Sao Paulo, Inst Biomed Sci, Dept Anat, Lab Funct Neuroanat Pain, Sao Paulo - Brazil
[2] Univ Sao Paulo, Dept Oral & Maxillofacial Surg, Sch Dent, Av Prof Linen Prestes 2227, Cidade Univ, BR-05508000 Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Lasers in Medical Science; v. 35, n. 2, p. 447-453, MAR 2020.
Web of Science Citations: 0
Abstract

This study analyzed the effects of photobiomodulation (PBM) with low-level laser therapy on nociceptive behavior and neuronal activity in the trigeminal nucleus after experimental unilateral temporomandibular joint (TMJ) disc injury. The animals were divided into 4 groups (n = 10 each): group 1, surgical injury of the articular disc and PBM; group 2, sham-operated subjected to PBM; group 3, surgical injury of the articular disc; and group 4, control (Naive). Ten sessions of PBM were performed using GaAs laser with a wavelength of 904 nm, power of 75 W pico, average power of 0.043 W, area of the beam of 0.13 cm(2), duration of the pulses of 60 nseg (in the frequency of 9500 Hz), energy density of 5.95 J/cm(2), energy per point of 0.7 J, and power density of 333.8 mW/cm(2), and the irradiation was done for 18 s per point. Neuropathic symptoms were evaluated using the von Frey test. Trigeminal ganglion samples underwent immunoblotting to examine the expression of substance P, vanilloid transient potential receptor of subtype-1 (TRPV-1), and peptide related to the calcitonin gene (CGRP). There was a total decrease in pain sensitivity after the second session of PBM in operated animals, and this decrease remains until the last session. There was a significant decrease in the expression of SP, TRPV-1, and CGRP after PBM. Photobiomodulation therapy was effective in reducing nociceptive behavior and trigeminal nucleus neuronal activity after TMJ disc injury. (AU)

FAPESP's process: 17/05218-5 - Effect of photobiostimulation on different peripheral neuropathies in rats.
Grantee:Marucia Chacur
Support Opportunities: Regular Research Grants