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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Determination of fast neutron RBE using a fully mechanistic computational model

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Zabihi, Azam [1] ; Tello, John [2] ; Incerti, Sebastien [3, 4] ; Francis, Ziad [5] ; Forozani, Ghasem [6] ; Semsarha, Farid [7] ; Moslehi, Amir [8] ; Bernal, Mario A. [2]
Total Authors: 8
[1] Bu Ali Sina Univ, Fac Sci, Dept Phys, Hamadan, Hamadan - Iran
[2] Univ Estadual Campinas, Inst Fis Gleb Wataghin, Campinas - Brazil
[3] Univ Bordeaux, CENBG, UMR 5797, F-33170 Gradignan - France
[4] CNRS, IN2P3, CENBG, UMR 5797, F-33170 Gradignan - France
[5] Univ St Joseph, Fac Sci, Dept Phys, Beirut - Lebanon
[6] Payame Noor Univ, Dept Phys, POB 19395-3697, Tehran - Iran
[7] Univ Tehran, Inst Biochem & Biophys, POB 13145-1384, Tehran - Iran
[8] Nucl Sci & Technol Res Inst, Radiat Applicat Res Sch, POB 11365-3486, Tehran - Iran
Total Affiliations: 8
Document type: Journal article
Source: Applied Radiation and Isotopes; v. 156, FEB 2020.
Web of Science Citations: 0

This work presents a model previously developed for estimating relative biological effectiveness (RBE) associated with high-LET particles. It is based on the combination of Monte Carlo simulations of particle interactions when traversing an atomic resolution DNA geometrical model. In addition, the model emulates the induction of lethal damage from the interaction of two sublethal lesions, taken as double-strand breaks. The Geant4-DNA package was used for simulations with liquid water as the transport medium. The RBE of neutron beams with energies ranging from 0.1 MeV up to 14 MeV was studied. The model succeeded in reproducing the general behavior of RBE as a function of neutron energy, including the RBE peak reported by experiments at approximately 0.4 MeV. Furthermore, the results of the model agree rather well with some experimental works. However, our results underestimate RBE for neutron energies above approximately 5 MeV due to the current limitations of Geant4-DNA for the tracking of heavy ions below 0.5 MeV/u. (AU)

FAPESP's process: 11/51594-2 - Development of a computational system for the simulation of the interaction of ionizing radiations with the human genetic material
Grantee:Mario Antonio Bernal Rodriguez
Support type: Research Grants - Young Investigators Grants
FAPESP's process: 18/15316-7 - Study of the interaction of heavy charged particles with DNA using computational methods
Grantee:Mario Antonio Bernal Rodriguez
Support type: Research Grants - Young Investigators Grants - Phase 2
FAPESP's process: 15/21873-8 - Establishment and application of methodologies for optimizing imaging techniques in digital radiology
Grantee:Alessandra Tomal
Support type: Regular Research Grants