| Full text | |
| Author(s): |
Spindola, Adauto
[1]
;
Targa, Adriano D. S.
[2, 3]
;
Rodrigues, Lais Soares
[2, 3]
;
Winnischofer, Sheila Maria Brochado
[4, 5]
;
Lima, Marcelo M. S.
[2, 3]
;
Sogayar, Mari Cleide
[1, 6]
;
Trombetta-Lima, Marina
[1]
Total Authors: 7
|
| Affiliation: | [1] Universidade Sao Paulo, Faculdade Medicina, Nucleo Terapia Celular Mol, NUCEL, BR-05360-130 Sao Paulo, SP - Brazil
[2] Universidade Fed Parana, Departamento Fisiol, Laboratorio Neurofisiol, BR-81531-990 Curitiba - Brazil
[3] Universidade Fed Parana, Departamento Farmacol, BR-81531-990 Curitiba - Brazil
[4] Universidade Fed Parana, Departamento BioQuim Biol Mol, BR-81531-990 Curitiba - Brazil
[5] Universidade Fed Parana, Departamento Biol Celular Mol, BR-81531-990 Curitiba - Brazil
[6] Universidade Sao Paulo, Departamento BioQuim, Instituto Quim, BR-05508-000 Sao Paulo, SP - Brazil
Total Affiliations: 6
|
| Document type: | Journal article |
| Source: | Molecular Neurobiology; v. 57, n. 2, p. 837-847, FEB 2020. |
| Web of Science Citations: | 0 |
| Abstract | |
Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder worldwide. Among its non-motor symptoms, sleep disorders are extremely common, being linked to cognitive and memory disruption. The microenvironment, particularly the extracellular matrix (ECM), is deeply involved in memory consolidation as well as in neuropathological processes, such as inflammation, damage to the blood-brain barrier and neuronal death. To better understand ECM dynamics in PD memory disturbances, we investigated the orchestrated expression of Mmps (Mmp-3, Mmp-7, and Mmp-9) and their modulators (Reck and Timp-3) in a rotenone-induced PD model. Also, we introduced an additional intervention in the memory process through rapid eye movement sleep deprivation (REMSD). We observed a REMSD-induced trend in reversing the memory impairment caused by rotenone administration. Associated to this phenotype, we observed a significant increase in Mmp-7/Reck and Mmp-9/Reck mRNA expression ratio in the substantia nigra and Mmp-9/Reck ratio in the hypothalamus. Moreover, the positive correlation of Mmp/Reck expression ratios between the substantia nigra and the striatum, observed upon rotenone infusion, was reversed by REMSD. Taken together, our results suggest a potential orchestrated association between an increase in Mmp-7 and Mmp-9/Reck expression ratios in the substantia nigra and a possible positive effect on cognitive performance in subjects affected by PD. (AU) | |
| FAPESP's process: | 16/18277-7 - ANALYSIS OF THE RECK TUMOR SUPPRESSOR GENE'S ROLE IN ASYMMETRIC CELL DIVISION |
| Grantee: | Marina Trombetta Lima |
| Support Opportunities: | Scholarships abroad - Research Internship - Post-doctor |
| FAPESP's process: | 16/05311-2 - Regenerative medicine aiming at therapy for chronic degenerative diseases (cancer and diabetes) |
| Grantee: | Mari Cleide Sogayar |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 15/26328-8 - Comparative analysis of the Reck tumor suppressor gene role in glioblastoma stem cell sub-population and in normal neural stem cells. |
| Grantee: | Marina Trombetta Lima |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |