| Full text | |
| Author(s): |
Bozi, Luiz H. M.
[1]
;
Campos, Juliane C.
[1]
;
Zambelli, Vanessa O.
[2]
;
Ferreira, Nikolas D.
[1]
;
Ferreira, Julio C. B.
[1, 3]
Total Authors: 5
|
| Affiliation: | [1] Univ Sao Paulo, Inst Biomed Sci, Sao Paulo - Brazil
[2] Butantan Inst, Sao Paulo - Brazil
[3] Stanford Univ, Dept Chem & Syst Biol, Sch Med, Stanford, CA 94305 - USA
Total Affiliations: 3
|
| Document type: | Review article |
| Source: | MOLECULAR ASPECTS OF MEDICINE; v. 71, FEB 2020. |
| Web of Science Citations: | 0 |
| Abstract | |
Disruption of mitochondrial function is a common feature of inherited mitochondrial diseases (mitochondriopathies) and many other infectious and non-infectious diseases including viral, bacterial and protozoan infections, inflammatory and chronic pain, neurodegeneration, diabetes, obesity and cardiovascular diseases. Mitochondria therefore become an attractive target for developing new therapies. In this review we describe critical mechanisms involved in the maintenance of mitochondrial functionality and discuss strategies used to identify and validate mitochondrial targets in different diseases. We also highlight the most recent preclinical and clinical findings using molecules targeting mitochondrial bioenergetics, morphology, number, content and detoxification systems in common pathologies. (AU) | |
| FAPESP's process: | 13/07937-8 - Redoxome - Redox Processes in Biomedicine |
| Grantee: | Ohara Augusto |
| Support Opportunities: | Research Grants - Research, Innovation and Dissemination Centers - RIDC |
| FAPESP's process: | 17/16071-5 - Contribution of the Mitocondrial Aldehyde dehydrogenase-2 Enzime on Neuropathic Pain. |
| Grantee: | Vanessa Olzon Zambelli |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 18/18627-3 - Mechanisms of exercise-induced mitophagy: a new avenue to drug discovery |
| Grantee: | Julio Cesar Batista Ferreira |
| Support Opportunities: | Scholarships abroad - Research |
| FAPESP's process: | 17/24836-1 - Role of autophagy in neurogenic myopathy |
| Grantee: | Nikolas Dresch Ferreira |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |
| FAPESP's process: | 17/16540-5 - Exercise, lifespan and healthspan: a molecular and longitudinal approach to study their interactions |
| Grantee: | Juliane Cruz Campos |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 17/16694-2 - Impact of 4-hydroxinonenal on DICER regulation: a translational approach |
| Grantee: | Julio Cesar Batista Ferreira |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 18/19332-7 - ALDH2 enzymatic activity regulates opioid drug tolerance |
| Grantee: | Vanessa Olzon Zambelli |
| Support Opportunities: | Scholarships abroad - Research |