| Full text | |
| Author(s): |
Santana, Harrson S.
[1]
;
Palma, Mauri S. A.
[2]
;
Lopes, Mariana G. M.
[1]
;
Souza, Johmar
[1]
;
Lima, Giovanni A. S.
[3]
;
Taranto, Osvaldir P.
[1]
;
Silva, Jr., Joao Lameu
[4]
Total Authors: 7
|
| Affiliation: | [1] Univ Estadual Campinas, Sch Chem Engn, BR-13083852 Campinas, SP - Brazil
[2] Univ Sao Paulo, Dept Biochem & Pharmaceut Technol, BR-05508000 Sao Paulo, SP - Brazil
[3] Univ Sao Paulo, Inst Environm Chem & Pharmaceut Sci Fed, BR-09972270 Diadema, SP - Brazil
[4] Fed Inst Educ Sci & Technol South Minas Gerais IF, BR-37560260 Pouso Alegre, MG - Brazil
Total Affiliations: 4
|
| Document type: | Review article |
| Source: | Industrial & Engineering Chemistry Research; v. 59, n. 9, p. 3794-3810, MAR 4 2020. |
| Web of Science Citations: | 1 |
| Abstract | |
Microfluidics and 3D printing will allow a faster research and development in pharmaceutical and medical areas, supporting new solutions for active pharmaceutical production and clinical tests without the necessity of in vivo animal models. The present review aims to show the role of these two technologies in the resolution of current pharmaceutical issues (e.g., efficient continuous production of active pharmaceutical ingredients, high costs for medicine development and lack of preclinical systems capable to predict accurate human responses to new medicine drugs) and in the development of biomedical and tissue engineering. The present paper was divided into the following sections: microfluidics and active pharmaceutical ingredients synthesis, organs-on-a-chip and multiorgans microdevices, 3D printing/bioprinting, and hydrogels and bioinks. Finally, conclusions and future perspectives are exposed. (AU) | |
| FAPESP's process: | 16/20842-4 - Development of a micro-chemical plant for biodiesel production |
| Grantee: | Osvaldir Pereira Taranto |
| Support Opportunities: | Regular Research Grants |