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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Histopathological features of photodamage and mast cell infiltrate in actinic cheilitis with different grades of epithelial dysplasia

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Author(s):
Santana, Thalita [1] ; Nagata, Gabriela [2] ; Saturno, Juvani Lago [1] ; Trierveiler, Marilia [1]
Total Authors: 4
Affiliation:
[1] Univ Sao Paulo, Sch Dent, Oral & Maxillofacial Pathol Dept, Sao Paulo - Brazil
[2] Herminio Ometto Univ Ctr, UNIARARAS, Sch Dent, Araras - Brazil
Total Affiliations: 2
Document type: Journal article
Source: JOURNAL OF CUTANEOUS PATHOLOGY; v. 47, n. 7 MAR 2020.
Web of Science Citations: 0
Abstract

Background Actinic cheilitis is induced by chronic exposure to ultraviolet radiation and shows solar elastosis, a feature that has been associated with mast cell infiltrates. This study aimed to investigate the area of solar elastosis, collagen loss, and mast cell infiltrates in a series of actinic cheilitis. Methods We evaluated the epithelial dysplasia in 52 cases of actinic cheilitis and the solar elastosis with Weigert's resorcin-fuchsin. Collagen loss was evaluated with Picrosirius red, analyzed under polarized microscopy, and scored from 1 to 3. Elastosis proportionate area (EPA) was calculated with image software. Mast cells were highlighted with toluidine blue stain. Results EPA varied from 2% to 45%, with a mean of 17.1% in the cases, with no differences among epithelial dysplasia degrees. Most cases presented collagen loss scores of 2 or 3, and higher loss of type I collagen was associated with older age. Mast cell density was higher in severe epithelial dysplasia (P = 0.002) and in high-risk cases (P = 0.01). Conclusion Actinic cheilitis presented variable EPA and marked loss of type I collagen; however, these features were not associated with the degrees of epithelial dysplasia. Besides, mast cell density increased with epithelial dysplasia worsening and this was not associated with elastosis area or collagen loss. (AU)