Silicon nitride with titania, calcia and silica additives for orthopaedic applications

Author(s)

Guedes-Silva, Cecilia C. ^[1] ; Rodas, Andrea C. D. ^[2] ; Carvalho, Flavio M. S. ^[3] ; Higa, Olga Z. ^[1] ; Ferreira, Thiago S. ^[1]

Affiliation

^[1] Nucl & Energy Res Inst, BR-05508000 Sao Paulo, SP - Brazil

^[2] Fed Univ ABC, Ctr Engn Modeling & Appl Social Sci, BR-09606045 Sao Bernardo Do Campo, SP - Brazil

^[3] Univ Sao Paulo, Geosci Inst, BR-05508080 Sao Paulo, SP - Brazil

• Document type: Journal article
• Source: PROCESSING AND APPLICATION OF CERAMICS; v. 14, n. 1, p. 63-70, 2020.
• Web of Science Citations: 0

Abstract

Titanium, silicon and calcium ions have demonstrated positive effects in bone healing. Therefore, this paper investigates the densification, mechanical properties and in vitro biological behaviour of TiO2, together with SiO2 and CaO, on silicon nitride ceramics to be used in clinical applications. The results revealed that the sintered samples reached high values of relative density and fracture toughness, non-cytotoxicity as well as good ability to promote cell proliferation and form a layer of carbonated hydroxyapatite on their surfaces, after immersion in simulated body fluid. The sample with the highest amount of TiO2 reached the highest value of relative density and the best results of cell proliferation and fracture toughness, indicating the great potential to be explored by in vivo experiments for later application as intervertebral devices. (AU)

• FAPESP's process: 15/02265-7 - Development of ceramic composites of Si3N4-SiO2-CaO system for bone compatibility
• Grantee: Cecília Chaves Guedes e Silva
• Support Opportunities: Regular Research Grants