| Full text | |
| Author(s): |
Jimenez, Paula C.
[1]
;
Wilke, Diego V.
[2]
;
Branco, Paola C.
[3]
;
Bauermeister, Anelize
[3]
;
Rezende-Teixeira, Paula
[3]
;
Gaudencio, Susana P.
[4]
;
Costa-Lotufo, Leticia V.
[3]
Total Authors: 7
|
| Affiliation: | [1] Univ Fed Sao Paulo, Dept Ciencias Mar, Santos, SP - Brazil
[2] Univ Fed Ceara, Fac Med, Dept Fisiol & Farmacol, NPDM, Fortaleza, CE - Brazil
[3] Univ Sao Paulo, Inst Ciencias Biomed, Dept Farmacol, BR-05508900 Sao Paulo, SP - Brazil
[4] NOVA Univ Lisbon, Fac Sci & Technol, Blue Biotechnol & Biomed Lab, UCIBIO, Dept Chem, Caparica - Portugal
Total Affiliations: 4
|
| Document type: | Review article |
| Source: | British Journal of Pharmacology; v. 177, n. 1, p. 3-27, JAN 2020. |
| Web of Science Citations: | 1 |
| Abstract | |
Marine natural products have proven, over the last half-century, to be effective biological modulators. These molecules have revealed new targets for cancer therapy as well as dissimilar modes of action within typical classes of drugs. In this scenario, innovation from marine-based pharmaceuticals has helped advance cancer chemotherapy in many aspects, as most of these are designated as first-in-class drugs. Here, by examining the path from discovery to development of clinically approved drugs of marine origin for cancer treatment-cytarabine (Cytosar-U (R)), trabectedin (Yondelis (R)), eribulin (Halaven (R)), brentuximab vedotin (Adcetris (R)), and plitidepsin (Aplidin (R))- together with those in late clinical trial phases-lurbinectedin, plinabulin, marizomib, and plocabulin-the present review offers a critical analysis of the contributions given by these new compounds to cancer pharmacotherapy. (AU) | |
| FAPESP's process: | 17/17648-4 - Integrative approach on the sustainable prospection of marine natural products: from diversity to anticancer compounds |
| Grantee: | Anelize Bauermeister |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 17/09022-8 - Inhibitory Apoptosis Proteins (IAPs) as therapeutic targets in melanoma: studies with prodiginines in vemurafenibe-resistant cells |
| Grantee: | Paola Cristina Branco |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 15/17177-6 - Integrative approach on the sustainable prospection of marine natural products: from diversity to anticancer compounds |
| Grantee: | Leticia Veras Costa Lotufo |
| Support Opportunities: | BIOTA-FAPESP Program - Thematic Grants |