Presence of the protein indoleamine 2,3-dioxygenase (IDO) in the maternal-fetal interface of the yolk sac placenta of blue shark, Prionace glauca

Author(s)

Salmon, Thierry ^[1] ; Bruno, Carlos Eduardo M. ^[1] ; de Amorim, Alberto Ferreira ^[2] ; Kfoury Junior, Jose Roberto ^[1]

Affiliation

^[1] Univ Sao Paulo, Fac Vet Med & Anim Sci, Dept Surg, Sect Anat, Sao Paulo - Brazil

^[2] SAA, Fisheries Inst, APTA Ctr Marine Fish, APTA, Sao Paulo, SP - Brazil

• Document type: Journal article
• Source: FISH & SHELLFISH IMMUNOLOGY; v. 100, p. 256-260, MAY 2020.
• Web of Science Citations: 0

Abstract

Indoleamine 2 3-dioxygenase (IDO) is a protein usually described in mammals, which, among other functions, participates in the maternal-fetal tolerance process. The blue-shark, Prionace glauca (Linnaeus, 1758) is a viviparous placentary species in which the yolk sac develops during the pregnancy, turning into a placenta for matrotrophic nutrition of the embryo. The purpose of this study was to investigate the expression of IDO in the P. glauca maternal-fetal interface along three gestation phases and describe its distribution and the meaning of its presence. The results showed IDO labelling during the yolk sac/placenta development in the ectoderm on the three development phases and in the endoderm at the two first phases. In the uterine epithelium, IDO was observed in the last two phases. These interface tissues are major contact areas between the mother and the semiallogeneic conceptus and this relation could induce an immunological response against the fetus. Therefore, the presence of IDO may indicate that it could have a similar role in the mechanism of maternal-fetal tolerance in the P. glauca placental interface, as described in eutherian mammals. (AU)

• FAPESP's process: 16/05259-0 - Study on blue marlin, Makaira nogricans (Osteichthyes, Istiophoridae) migration in the South Western Atlantic
• Grantee: Alberto Ferreira de Amorim
• Support Opportunities: Regular Research Grants