Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Detection of Fusobacterium in oral and head and neck cancer samples: A systematic review and meta-analysis

Full text
Author(s):
Bronzato, Juliana D. [1, 2] ; Bomfim, Rafael A. [3] ; Edwards, David H. [2] ; Crouch, Dorothy [2] ; Hector, Mark P. [2] ; Gomes, Brenda P. F. A. [1]
Total Authors: 6
Affiliation:
[1] State Univ Campinas UNICAMP, Piracicaba Dent Sch, Piracicaba, SP - Brazil
[2] Univ Dundee, Dent Sch, Pk Pl, Dundee DD1 5HR - Scotland
[3] Univ Fed Mato Grosso do Sul, Sch Dent, Campo Grande, MS - Brazil
Total Affiliations: 3
Document type: Review article
Source: ARCHIVES OF ORAL BIOLOGY; v. 112, APR 2020.
Web of Science Citations: 13
Abstract

Aims: This systematic review aimed to analyse: a) the presence and the abundance of Fusobacterium; b) the Fusobacterium species most often found, and c) the most common methods used for their identification in oral/ head and neck cancer samples. Design: A protocol was registered on PROSPERO database. This review was conducted following PRISMA guidelines. Literature search was performed on five electronic biomedical databases, namely Pubmed, Scopus, Web of Science, Embase, and Cochrane from their start dates to 30 August 2018. Two reviewers independently assessed the eligibility for inclusion; extracted the data; and evaluated the risk of bias. Results: From 118 unique abstract records, 88 full-text articles were assessed for eligibility. According to inclusion and exclusion criteria, 17 publications were included in this review. Meta-analysis showed an increased prevalence of 6 % (95 % CI, 3-9) of Fusobacterium in tumour lesions than in non-tumour lesions (Fusobacterium prevalence of 16 % in tumour lesions and of 10 % in non-tumour lesions), and a 2.93 higher chance of Fusobacterium being present in tumour lesions (95 % CI, 1.47-5.81). The most common detection methods were based on molecular evidence (64.70 %) (95 % CI, 37.7-84.7). F. nucleatum was the most prevalent species (47.06 %) (95 % CI, 23.5-72). Conclusion: In conclusion, Fusobacterium is present and in higher abundance in oral/head and neck cancer samples when compared to non-cancer samples, suggesting that Fusobacterium may contribute to oral/head and neck cancer development. (AU)

FAPESP's process: 15/23479-5 - Microbiomes and immunobiological aspects in endodontic infections
Grantee:Brenda Paula Figueiredo de Almeida Gomes
Support Opportunities: Research Projects - Thematic Grants