On the mechanical biocompatibility of Ti-15Zr-based alloys for potential use as load-bearing implants

Author(s)

Correa, D. R. N. ^{[1, 2]} ; Rocha, L. A. ^{[1, 3]} ; Donato, T. A. G. ^{[1, 3]} ; Sousa, K. S. J. ^[3] ; Grandini, C. R. ^{[1, 3]} ; Afonso, C. R. M. ^[4] ; Doi, H. ^[5] ; Tsutsumi, Y. ^{[5, 6]} ; Hanawa, T. ^[5]

Affiliation

^[1] IBTN Br Inst Biomat Tribocorros & Nanomed, Brazilian Branch, BR-17033360 Bauru, SP - Brazil

^[2] IFSP Fed Inst Educ Sci & Technol, Grp Pesquisa Mat Met Avancados, BR-18095410 Sorocaba, SP - Brazil

^[3] Univ Estadual Paulista, Lab Anelasticidade & Biomat, UNESP, BR-17033360 Bauru, SP - Brazil

^[4] UFSCar Univ Sao Carlos, Dept Mat Engn, BR-13565905 Sao Carlos, SP - Brazil

^[5] Tokyo Med & Dent Univ, Inst Biomat & Bioengn, Chiyoda Ku, Tokyo 1010062 - Japan

^[6] Natl Inst Mat Sci, Res Ctr Struct Mat, Tsukuba, Ibaraki 3050047 - Japan

• Document type: Journal article
• Source: JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T; v. 9, n. 2, p. 1241-1250, MAR-APR 2020.
• Web of Science Citations: 0

Abstract

This study evaluated the mechanical properties and cytocompatibility of recently developed Ti-15Zr-based alloys with Mo addition for potential use as load-bearing implants. The phase composition and microstructure were changed by the alloying elements, being the beta phase fully retained on the Ti-15Zr-10Mo and Ti-15Zr-15Mo samples. The TEM analysis showed that a small quantity of omega phase was precipitated on the samples with a high amount of Mo. Regarding the mechanical properties, the Ti-15Zr-10Mo sample presented high mechanical strength and large elongation (854 +/- 63 MPa and 18.7 +/- 2.8 %). However, the Ti-15Zr-15Mo sample exhibited better mechanical compatibility, due to its combination of low Young's modulus (75 +/- 1 GPa) and high Vickers microhardness (346 +/- 4 HV). Some dimple-type structures found along the fractured surface confirmed the ductile behavior of these samples. The MTT test indicated non-cytotoxic effects of all samples when in contact with osteoblastic cells (p < 0.05). The wettability values of the samples were adequate for biomedical applications. The mechanical properties of the Ti-15Zr-15Mo sample were better than some commercial metallic biomaterials, which highlights its great potential for use as load-bearing implants. (C) 2019 The Authors. Published by Elsevier B.V. (AU)

• FAPESP's process: 10/20440-7 - Effect of substitutional and interstitial elements in the mechanical properties and biocompatibility of Ti-15Zr-xMo alloys
• Grantee: Diego Rafael Nespeque Correa
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• FAPESP's process: 15/00851-6 - Biofunctionalization of Ti-15Zr-BASED alloys with molybdenum addition and some surface modifications
• Grantee: Diego Rafael Nespeque Correa
• Support Opportunities: Scholarships in Brazil - Post-Doctoral