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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The P2X7 Receptor in the Maintenance of Cancer Stem Cells, Chemoresistance and Metastasis

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Author(s):
Arnaud-Sampaio, Vanessa Fernandes [1] ; Alves Rabelo, Izadora Lorrany [1] ; Ulrich, Henning [1] ; Lameu, Claudiana [1]
Total Authors: 4
Affiliation:
[1] Univ Sao Paulo, Inst Quim, Dept Bioquim, Av Lineu Prestes 748, BR-05508900 Sao Paulo, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: STEM CELL REVIEWS AND REPORTS; v. 16, n. 2, p. 288-300, APR 2020.
Web of Science Citations: 0
Abstract

Metastasis is the worst prognosis predictor in the clinical course of cancer development. Features of metastatic cancer cells include migratory ability, low degree of differentiation, self-renewal and proliferation potentials, as well as resistance to therapies. Metastatic cells do not present all of the necessary characteristics at once. Indeed, they have a unique phenotypic plasticity, allowing the acquisition of features that make them successful in all steps of metastasis. Cancer stem cells (CSC), the most undifferentiated cells in the tumor mass, display highest metastatic potential and resistance to radio- and chemotherapy. Growing tumors exhibit marked upregulation of P2X7 receptor expression and secrete ATP. Since the P2X7 receptor plays an important role in the maintenance of undifferentiated state of pluripotent cells, its importance on cell fate regulation in the tumor mass is suggested. Considering the extensive crosstalk between CSCs, epithelial-mesenchymal transition, drug resistance and metastasis, current knowledge implicating P2X7 receptor function in these phenomena and new avenues for therapeutic strategies to control metastasis are reviewed. (AU)

FAPESP's process: 15/19128-2 - Metastasis mechanisms of childhood tumors to bone marrow
Grantee:Claudiana Lameu
Support Opportunities: Research Grants - Young Investigators Grants
FAPESP's process: 18/07366-4 - Purine and kinin receptors as targets of study and therapeutic interventions in neurological diseases
Grantee:Alexander Henning Ulrich
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 17/06132-7 - Study of P2X7 receptor isoforms in the maintenance of cancer stem cells and metastasis
Grantee:Izadora Lorrany Alves Rabelo
Support Opportunities: Scholarships in Brazil - Doctorate (Direct)