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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Cocrystals of ciprofloxacin with nicotinic and isonicotinic acids: Mechanochemical synthesis, characterization, thermal and solubility study

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Author(s):
de Almeida, Amanda Cosmo [1] ; Torquetti, Carolina [2] ; Ferreira, Patricia Osorio [1] ; Fernandes, Richard Perosa [1] ; dos Santos, Everton Carvalho [2] ; Kogawa, Ana Carolina [3] ; Caires, Flavio Junior [1, 2]
Total Authors: 7
Affiliation:
[1] Sao Paulo State Univ UNESP, Inst Chem, Araraquara, SP - Brazil
[2] Sao Paulo State Univ UNESP, Sch Sci, Bauru, SP - Brazil
[3] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, Araraquara, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Thermochimica Acta; v. 685, MAR 2020.
Web of Science Citations: 0
Abstract

This article describes the synthesis and characterization of new cocrystals of ciprofloxacin with nicotinic and isonicotinic acids as coformers. The cocrystals were obtained by a mechanochemical method (neat and liquid-assisted grinding). The characterization of the cocrystals was carried out using differential scanning calorimetry (DSC), thermogravimetry and simultaneous differential thermal analysis (TG-DTA), infrared spectroscopy (IR), and powder X-ray diffractometry (PXRD). Using these thermal, spectroscopic and diffractometric methods it was possible to verify the formation of the cocrystals, either with or without the addition of ethanol. Additionally, binary phase diagrams, constructed from the data of the DSC curves, confirmed the formation of the cocrystals and their stoichiometry; 1:1 (mol/mol) was determined as the optimal stoichiometric ratio. Furthermore, the formed cocrystals were capable of improving the aqueous solubility of the bioactive agent used in this study. (AU)

FAPESP's process: 13/09022-7 - Thermoanalytical studies, synthesis and characterization of the solid co-crystals of antibiotics (fluoroquinolones) with some co-formers
Grantee:Massao Ionashiro
Support Opportunities: Regular Research Grants
FAPESP's process: 18/24378-6 - Synthesis, characterization and thermoanalytical study of Valsartan, Candesartan Cilexetil and Olmesartan medoxomil co-crystals
Grantee:Flávio Junior Caires
Support Opportunities: Regular Research Grants
FAPESP's process: 17/14936-9 - Preparation, characterization and thermoanalytical studies of heterogeneous catalysts of double selenates of Mg/Co and Mg/Cu in biodiesel production using different oils
Grantee:Massao Ionashiro
Support Opportunities: Regular Research Grants