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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Cardiovascular and Autonomic Dysfunction in Murine Ligature-Induced Periodontitis

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Author(s):
Ribeiro, Aline Barbosa [1] ; Santos-Junior, Nilton Nascimento [1] ; Luiz, Joao Paulo Mesquita [2] ; de Oliveira, Mauro [1] ; Kanashiro, Alexandre [3] ; Taira, Thaise Mayumi [4] ; Fukada, Sandra Yasuyo [4] ; Alves-Filho, Jose Carlos [2] ; Fazan Junior, Rubens [1] ; Salgado, Helio Cesar [1]
Total Authors: 10
Affiliation:
[1] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Physiol, Ribeirao Preto, SP - Brazil
[2] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Pharmacol, Ribeirao Preto, SP - Brazil
[3] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Neurosci & Behav, Ribeirao Preto, SP - Brazil
[4] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, Dept Bio Mol Sci, Ribeirao Preto, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: SCIENTIFIC REPORTS; v. 10, n. 1 APR 23 2020.
Web of Science Citations: 0
Abstract

The present study examined the hemodynamics {[}arterial pressure (AP), AP variability (APV), heart rate (HR), and heart rate variability (HRV)], cardiac function (echocardiographycally), and myocardial inflammation in Balb/c mice submitted to Periodontitis, through the ligation of the left first molar, or Sham surgical procedure. The first protocol indicated that the AP was similar (136 +/- 2 vs. 132 +/- 3mmHg in Sham), while the HR was higher in mice with Periodontitis (475 +/- 20 vs. 412 +/- 18 bpm in Sham), compared to their Sham counterparts. The APV was higher in mice with Periodontitis when evaluated in the time domain (4.5 +/- 0.3 vs. 3.4 +/- 0.2mmHg in Sham), frequency domain (power of the LF band of systolic AP), or through symbolic analysis (patterns 0V+1V), indicating a sympathetic overactivity. The HRV was similar in the mice with Periodontitis, as compared to their Sham counterparts. In the second protocol, the mice with Periodontitis showed decreased cardiac output (10 +/- 0.8 vs. 15 +/- 1.4mL/min in Sham) and ejection fraction (37 +/- 3 vs. 47 +/- 2% in Sham) associated with increased myocardial cytokines (Interleukin-17, Interleukin-6, and Interleukin-4). This study shows that experimental Periodontitis caused cardiac dysfunction, increased heart cytokines, and sympathetic overactivity, in line with epidemiological studies indicating an increased risk of cardiovascular events in clinical Periodontitis. (AU)

FAPESP's process: 18/20939-3 - New insights in Cardiovascular Regulation under Physiological and Pathophysiological Condition.
Grantee:Nilton Nascimento dos Santos Júnior
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 13/20549-7 - New insights in cardiovascular regulation under physiological and pathophysiological condition
Grantee:Helio Cesar Salgado
Support type: Research Projects - Thematic Grants
FAPESP's process: 18/10455-9 - Role of electrical activaton of the carotid sinus nerve, in conscious rats, in the attenuation of local and systemic inflammatory response elicited by periodontitis.
Grantee:Aline Barbosa Ribeiro
Support type: Scholarships in Brazil - Post-Doctorate