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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Diethyl Selenodiglycolate: An Eco-Friendly Synthetic Antioxidant with Potential Application to Inflammatory Disorders

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Author(s):
Pinatto-Botelho, Marcos F. [1, 2] ; da Silva, Railmara P. [3] ; Archilha, Marcos V. L. R. [1, 2] ; Giroldo, Lilian [1] ; Kuznetsov, Aleksey E. [4] ; Meotti, Flavia C. [3] ; dos Santos, Alcindo A. [1]
Total Authors: 7
Affiliation:
[1] Univ Sao Paulo, Inst Quim, Dept Quim Fundamental, Sao Paulo 05508000, SP - Brazil
[2] Univ Sao Paulo, SelenoLife, Ctr Inovacao Empreendedorismo & Tecnol CIETEC, IPEN, Sao Paulo 05508000, SP - Brazil
[3] Univ Sao Paulo, Inst Quim, Dept Bioquim, Sao Paulo 05508000, SP - Brazil
[4] Univ Tecn Federico Santa Maria, Dept Chem, Av Santa Maria 6400, Santiago 7660251 - Chile
Total Affiliations: 4
Document type: Journal article
Source: Journal of the Brazilian Chemical Society; v. 31, n. 6, p. 1239-1248, JUN 2020.
Web of Science Citations: 0
Abstract

This study describes a single step, high yield and purity, ecofriendly and scalable procedure to prepare a selenium derivative (diethyl selenodiglycolate). Diethyl selenodiglycolate rapidly reduces hypochlorous acid (HOCl, second-order rate constant of 7 × 107 M−1 s−1) to generate its corresponding selenoxide. In activated HL-60 cells, diethyl selenodiglycolate selectively reacted with HOCl (half maximal inhibitory concentration (IC50) = 23.07 µM) but not with superoxide anion radical or hydrogen peroxide without any cytotoxicity. These results show that this synthetically simple selenide reacts in a very efficient and specific way with the harmful pro-oxidant HOCl being a promising compound to be applied in oxidative inflammatory-related conditions. (AU)

FAPESP's process: 15/21563-9 - Study of the paper uric acid and redox modulation on the system cell innate immune microbicide activity
Grantee:Railmara Pereira da Silva
Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 13/07937-8 - Redoxome - Redox Processes in Biomedicine
Grantee:Ohara Augusto
Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC